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Query: NC_017375:1498000:1514604 Helicobacter pylori 83 chromosome, complete genome

Start: 1514604, End: 1515998, Length: 1395

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011333:1040192:1077383107738310787771395Helicobacter pylori G27 chromosome, complete genomehypothetical protein0722
NC_014555:1526775:1569202156920215705961395Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein0717
NC_017376:57500:6747567475688691395Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein0707
NC_017358:220900:2589242589242602581335Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein0689
NC_010698:870312:8809158809158821831269Helicobacter pylori Shi470, complete genomehypothetical protein0687
NC_014560:1366747:1379519137951913808291311Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein0655
NC_017367:278916:316589316589317041453Helicobacter pylori F57, complete genomehypothetical protein4e-55216
NC_017367:278916:317023317023317439417Helicobacter pylori F57, complete genomehypothetical protein1e-37157
NC_017367:278916:316047316047316295249Helicobacter pylori F57, complete genomehypothetical protein3e-37156
NC_011498:448000:4594054594054604691065Helicobacter pylori P12, complete genomehypothetical protein1e-1378.2
NC_000921:1007519:104910710491071049874768Helicobacter pylori J99, complete genomehypothetical protein5e-0962.8