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Query: NC_017375:1498000:1517584 Helicobacter pylori 83 chromosome, complete genome

Start: 1517584, End: 1518234, Length: 651

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017367:278916:3174963174963196132118Helicobacter pylori F57, complete genomehypothetical protein5e-108390
NC_011333:1040192:1078838107883810810512214Helicobacter pylori G27 chromosome, complete genomeperiplasmic competence protein-like protein2e-105381
NC_010698:870312:8787308787308808712142Helicobacter pylori Shi470, complete genomehypothetical protein2e-104378
NC_017361:930280:9385279385279407222196Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein5e-104376
NC_017361:1528239:1561161156116115633562196Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein5e-104376
NC_014560:1366747:1377248137724813794582211Helicobacter pylori SJM180 chromosome, complete genomeperiplasmic competence protein-like protein1e-103375
NC_017358:220900:2603022603022624942193Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-103374
NC_017371:1030148:1062302106230210644732172Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein5e-78290
NC_011498:448000:457332457332457577246Helicobacter pylori P12, complete genomehypothetical protein1e-39162
NC_000921:1007519:1049874104987410518802007Helicobacter pylori J99, complete genomehypothetical protein8e-39160
NC_011498:448000:4577914577914592721482Helicobacter pylori P12, complete genomehypothetical protein2e-30132
NC_000921:1007519:105167310516731052110438Helicobacter pylori J99, complete genomehypothetical protein7e-23107
NC_017371:1601452:1623564162356416250031440Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein8e-1270.5
NC_017354:1465925:1483617148361714850561440Helicobacter pylori 52 chromosome, complete genomeperiplasmic competence protein2e-1065.9
NC_017378:1489818:1511717151171715131561440Helicobacter pylori Puno120 chromosome, complete genomeperiplasmic competence protein2e-1065.5
NC_017367:1505780:1526235152623515276741440Helicobacter pylori F57, complete genomeperiplasmic competence protein5e-1064.7
NC_014555:1477934:1495630149563014970721443Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein6e-1064.3
NC_017365:1466500:1487305148730514887441440Helicobacter pylori F30, complete genomeperiplasmic competence protein8e-1063.9