Pre_GI: BLASTP Hits

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Query: NC_017375:1498000:1502086 Helicobacter pylori 83 chromosome, complete genome

Start: 1502086, End: 1502544, Length: 459

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017354:1465925:1472549147254914746992151Helicobacter pylori 52 chromosome, complete genomeputative cytoplasmic protein2e-79293
NC_017365:1466500:1476317147631714784552139Helicobacter pylori F30, complete genomehypothetical protein2e-78290
NC_017367:1505780:1515283151528315174362154Helicobacter pylori F57, complete genomehypothetical protein2e-75280
NC_014555:1477934:1484566148456614867492184Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein9e-66248
NC_000915:1583967:159490815949081595660753Helicobacter pylori 26695, complete genomehypothetical protein4e-65246
NC_011498:1571840:1580020158002015820232004Helicobacter pylori P12, complete genomehypothetical protein2e-30131
NC_017279:29737:5000150001521272127Campylobacter jejuni subsp. jejuni IA3902 chromosome, completeputative cytoplasmic protein1e-28125
NC_007759:2097734:2116066211606621182132148Syntrophus aciditrophicus SB, complete genomehypothetical cytosolic protein2e-2097.8
NC_012440:1215838:1226727122672712289462220Persephonella marina EX-H1, complete genomemacrophage infection protein, MimD3e-1890.5
NC_013890:191616:2130562130562152212166Dehalococcoides sp. GT chromosome, complete genomehypothetical protein5e-1683.2
NC_014507:374359:3935943935943957952202Methanoplanus petrolearius DSM 11571 chromosome, complete genomeputative cytoplasmic protein2e-1374.3
NC_009077:4810379:4822291482229148244772187Mycobacterium sp. JLS, complete genomeconserved hypothetical cytosolic protein4e-1373.6
NC_015593:2103815:2112987211298721151642178Sphingobium chlorophenolicum L-1 chromosome chromosome 1, completehypothetical protein7e-1372.8
NC_012673:2535427:2535427253542725376942268Exiguobacterium sp. AT1b, complete genomeputative cytoplasmic protein2e-1168.2
NC_015601:726962:7361827361827383652184Erysipelothrix rhusiopathiae str. Fujisawa, complete genomehypothetical protein3e-0650.8