Pre_GI Gene

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Host: NC_014560 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_014560:1366747 Helicobacter pylori SJM180 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated from an Amerindian resident of San Juan Miraflores shantytown in Lima Peru with gastritis. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
136674713681411395hypothetical proteinBLASTP
136814413692771134putative histidine kinase sensor proteinQuickGO ontologyBLASTP
13693121369953642response regulatorQuickGO ontologyBLASTP
137003613717991764type IIS restriction enzyme R protein MBOIIRQuickGO ontologyBLASTP
13718941372103210hypothetical protein
13723411373312972integraserecombinase XercD family proteinQuickGO ontologyBLASTP
13733021373415114integraserecombinase XercD family proteinQuickGO ontologyBLASTP
13734981374181684hypothetical proteinBLASTP
137425313755121260hypothetical proteinBLASTP
13755141375792279hypothetical proteinBLASTP
137584413772441401hypothetical proteinBLASTP
137724813794582211periplasmic competence protein-like proteinQuickGO ontologyBLASTP
137951913808291311hypothetical proteinBLASTP
138083013818671038hypothetical proteinBLASTP
138201713905218505adenine specific DNA methyltransferaseQuickGO ontologyBLASTP
13906721390890219hypothetical proteinBLASTP
139088013929402061topoisomerase IQuickGO ontologyBLASTP
13929951393465471hypothetical proteinBLASTP
13934351394238804hypothetical proteinBLASTP
13943121394977666hypothetical proteinBLASTP
13949551395347393hypothetical proteinBLASTP
13953941396062669hypothetical proteinBLASTP
13967001396864165hypothetical proteinBLASTP
13968651397845981hypothetical proteinBLASTP
139784513998211977hypothetical proteinBLASTP
139983114012641434hypothetical proteinBLASTP
140126114025291269hypothetical proteinBLASTP
140252614038031278hypothetical proteinBLASTP
14038401404820981hypothetical proteinBLASTP
14050531406033981hypothetical proteinBLASTP
14062031406886684hypothetical proteinBLASTP
14070111407262252hypothetical proteinBLASTP
14072791408148870possible cell division proteinQuickGO ontologyBLASTP
140846514095321068integraserecombinase xerDQuickGO ontologyBLASTP