Pre_GI Gene

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Host: NC_010698 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010698:870312 Helicobacter pylori Shi470, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori Shi470 is a clinical isolate from gastric antrum from Amerindian resident of remote Amazonian village of Shimaa, Peru. Helicobacter pylori chronically infects stomachs of billions of people worldwide, is implicated in peptic ulcer disease and gastric cancer, and is very diverse genetically. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8703128713731062phospho-N-acetylmuramoyl-pentapeptide- transferaseQuickGO ontologyBLASTP
871498872340843hypothetical proteinBLASTP
87244087262818950S ribosomal protein L28QuickGO ontologyBLASTP
8727788739141137putative potassium channel proteinQuickGO ontologyBLASTP
873916874311396hypothetical proteinBLASTP
874327874701375hypothetical proteinBLASTP
8749988760741077integraserecombinase xerDQuickGO ontologyBLASTP
8761398773411203hypothetical proteinBLASTP
8773418787261386hypothetical proteinBLASTP
8787308808712142hypothetical proteinBLASTP
8809158821831269hypothetical proteinBLASTP
8821848832211038hypothetical proteinBLASTP
8833758917868412hypothetical proteinBLASTP
892053892709657PARA proteinQuickGO ontologyBLASTP
892794893063270hypothetical proteinBLASTP
8930958942731179hypothetical proteinBLASTP
8942988962051908hypothetical proteinBLASTP
896499896813315hypothetical proteinBLASTP
896806897087282hypothetical proteinBLASTP
8973628990891728conjugal transfer protein traGQuickGO ontologyBLASTP
899090899647558hypothetical proteinBLASTP
899648899938291hypothetical proteinBLASTP
899935900390456hypothetical proteinBLASTP
900387901328942VIRB11QuickGO ontologyBLASTP
901328901627300hypothetical proteinBLASTP
901624901887264hypothetical proteinBLASTP
902009902173165hypothetical proteinBLASTP
90217090225687hypothetical proteinBLASTP
9022439034781236ComB3 proteinQuickGO ontologyBLASTP
9034759050161542Component of conjugal plasmid transfer systemQuickGO ontologyBLASTP
905016906002987hypothetical proteinBLASTP
906004906132129hypothetical proteinBLASTP
9061329080661935topoisomerase IQuickGO ontologyBLASTP
9080599105572499DNA transfer proteinQuickGO ontologyBLASTP