Pre_GI Gene

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Host: NC_017361 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017361:1528239 Helicobacter pylori SouthAfrica7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
15282391528532294hypothetical proteinBLASTP
152853915300651527hypothetical proteinBLASTP
15300621530364303hypothetical proteinBLASTP
15303651530631267hypothetical proteinBLASTP
153062415330472424VirB4-like proteinQuickGO ontologyBLASTP
15330501533940891DNA topoisomerase I topAQuickGO ontologyBLASTP
15339881534404417IS200 insertion sequence from SARA17QuickGO ontologyBLASTP
153444115357691329IS606 transposaseQuickGO ontologyBLASTP
153581715370521236DNA topoisomerase I topAQuickGO ontologyBLASTP
153716915383321164VirB8 type IV secretion proteinQuickGO ontologyBLASTP
153833215398641533VirB9 type IV secretion proteinQuickGO ontologyBLASTP
153986115411231263VirB10 type IV secretion proteinQuickGO ontologyBLASTP
15411931541486294hypothetical proteinBLASTP
15414791541799321hypothetical protein
15418021542104303hypothetical protein
15421011543072972type IV secretion system ATPase virB11-like proteinQuickGO ontologyBLASTP
15430691543542474hypothetical proteinBLASTP
15435441543801258hypothetical protein
154390115460332133conjugal transfer protein traGQuickGO ontologyBLASTP
15462541546550297hypothetical protein
15466061546917312hypothetical protein
154688515488731989hypothetical proteinBLASTP
15489001549169270hypothetical proteinBLASTP
15492471549909663PARA proteinQuickGO ontologyBLASTP
155017615585848409hypothetical proteinBLASTP
155878115597881008hypothetical proteinBLASTP
156116115633562196hypothetical proteinBLASTP
156336615647661401hypothetical proteinBLASTP
15648181565096279hypothetical proteinBLASTP
156509815663601263hypothetical proteinBLASTP