Pre_GI Gene

Some Help

Host: NC_011498 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011498:448000 Helicobacter pylori P12, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4480024491831182type I R-M system S proteinQuickGO ontologyBLASTP
4491764508071632type I R-M system M proteinQuickGO ontologyBLASTP
4524234534961074integraserecombinase XercD familyQuickGO ontologyBLASTP
453578454261684hypothetical proteinBLASTP
4543344556321299VirB6 type IV secretion proteinQuickGO ontologyBLASTP
455598455876279hypothetical proteinBLASTP
4559284573281401hypothetical proteinBLASTP
457332457577246hypothetical proteinBLASTP
4577914592721482hypothetical proteinBLASTP
4594054604691065hypothetical proteinBLASTP
460312460803492hypothetical proteinBLASTP
4608104618321023hypothetical proteinBLASTP
4620964705228427DNA methylaseQuickGO ontologyBLASTP
470785471441657chromosome partitioning proteinQuickGO ontologyBLASTP
471523471807285hypothetical proteinBLASTP
4718394730171179hypothetical proteinBLASTP
4730424749551914relaxaseQuickGO ontologyBLASTP
475253475567315hypothetical proteinBLASTP
475560475841282hypothetical proteinBLASTP
4761054778321728VirD4 coupling proteinQuickGO ontologyBLASTP
477879478391513hypothetical proteinBLASTP
478392478682291hypothetical proteinBLASTP
478679479134456hypothetical proteinBLASTP
479131480072942VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
480072480371300hypothetical proteinBLASTP
480368480631264hypothetical proteinBLASTP
480624480917294hypothetical proteinBLASTP
4809874822521266VirB10 type IV secretion proteinQuickGO ontologyBLASTP
4822524837841533VirB9 type IV secretion proteinQuickGO ontologyBLASTP
4837844849531170VirB8 type IV secretion proteinQuickGO ontologyBLASTP
484957485073117VirB7 type IV secretion proteinQuickGO ontology
489522489788267VirB3 type IV secretion proteinQuickGO ontologyBLASTP