Pre_GI Gene

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Host: NC_017361 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017361:930280 Helicobacter pylori SouthAfrica7 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
930280930657378translation initiation inhibitorQuickGO ontologyBLASTP
930727930891165hypothetical protein
931266931568303protein tRNA-associated locus proteinQuickGO ontologyBLASTP
93163293171887tRNA-LeuQuickGO ontology
93188993197688tRNA-SerQuickGO ontologyBLASTP
9321039335931491hypothetical proteinBLASTP
933868934230363hypothetical protein
9347909358661077integrase-recombinase proteinQuickGO ontologyBLASTP
9359309371321203hypothetical proteinBLASTP
9371329385171386hypothetical proteinBLASTP
9385279407222196hypothetical proteinBLASTP
9420959431021008hypothetical proteinBLASTP
9432999517078409hypothetical proteinBLASTP
951974952630657PARA proteinQuickGO ontologyBLASTP
952709952993285hypothetical proteinBLASTP
9530209541921173hypothetical proteinBLASTP
9542129561221911hypothetical proteinBLASTP
956537956851315hypothetical proteinBLASTP
956844957125282hypothetical proteinBLASTP
9572629590071746VirD4 coupling proteinQuickGO ontologyBLASTP
959008959565558hypothetical proteinBLASTP
959566959856291hypothetical proteinBLASTP
959853960308456hypothetical proteinBLASTP
960305961246942VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
961246961545300hypothetical proteinBLASTP
961542961805264hypothetical proteinBLASTP
961795962091297hypothetical proteinBLASTP
9621619633961236competence proteinQuickGO ontologyBLASTP
9633939649341542comB9-like competence proteinQuickGO ontologyBLASTP
964934965920987hypothetical proteinBLASTP
965922966050129hypothetical proteinBLASTP
9660509679931944topoisomerase IQuickGO ontologyBLASTP
9679779704752499DNA transfer proteinQuickGO ontologyBLASTP