Pre_GI Gene

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Host: NC_017371 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017371:1030148 Helicobacter pylori Gambia94/24 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
103014810313051158cell division protein FtsZQuickGO ontologyBLASTP
10330341033174141hypothetical proteinBLASTP
10332231034047825hypothetical proteinBLASTP
1034212103431099hypothetical protein
103455210364771926DNA transfer proteinQuickGO ontologyBLASTP
103647010380651596topoisomerase IQuickGO ontologyBLASTP
103806210392791218conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
103927610405231248competence proteinQuickGO ontologyBLASTP
1040498104059396hypothetical protein
10405961040892297hypothetical proteinBLASTP
10408821041145264hypothetical proteinBLASTP
10411421041441300hypothetical proteinBLASTP
10414411042382942VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
10423791042834456hypothetical proteinBLASTP
10428311043121291hypothetical proteinBLASTP
10431221043679558hypothetical proteinBLASTP
104368010454281749VirD4 coupling proteinQuickGO ontologyBLASTP
10456731045807135hypothetical proteinBLASTP
10459481046262315hypothetical proteinBLASTP
104859310497711179hypothetical proteinBLASTP
10498151050099285hypothetical proteinBLASTP
10501821050838657chromosome partitioning protein ParAQuickGO ontologyBLASTP
10596901059836147hypothetical protein
106230210644732172hypothetical proteinBLASTP