Pre_GI Gene

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Host: NC_017358 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_017358:220900 Helicobacter pylori Cuz20 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2209002239293030hypothetical proteinBLASTP
2240292251351107ATP-binding proteinQuickGO ontologyBLASTP
2251492261681020lipopolysaccharide 12-glycosyltransferaseQuickGO ontologyBLASTP
226192226305114lipopolysaccharide 12-glycosyltransferaseQuickGO ontology
2263532278071455hypothetical proteinBLASTP
227880228644765hypothetical proteinBLASTP
2286552305711917hypothetical proteinBLASTP
230561230863303hypothetical proteinBLASTP
230864231124261hypothetical proteinBLASTP
2311372336352499DNA transfer proteinQuickGO ontologyBLASTP
2336282355621935topoisomerase IQuickGO ontologyBLASTP
235562235690129hypothetical proteinBLASTP
235692236678987hypothetical proteinBLASTP
2366782382191542conjugal plasmid transfer system proteinQuickGO ontologyBLASTP
2382162394511236competence proteinQuickGO ontologyBLASTP
23943823952487hypothetical proteinBLASTP
239521239814294hypothetical proteinBLASTP
239807240070264hypothetical proteinBLASTP
240067240333267hypothetical proteinBLASTP
240365241306942VirB11QuickGO ontologyBLASTP
241303241731429hypothetical proteinBLASTP
241756242046291hypothetical proteinBLASTP
242047242604558hypothetical proteinBLASTP
2426052443321728conjugal transfer protein traGQuickGO ontologyBLASTP
244607244888282hypothetical proteinBLASTP
244881245195315hypothetical proteinBLASTP
2454762473831908hypothetical proteinBLASTP
2474082485921185hypothetical proteinBLASTP
248624248893270hypothetical proteinBLASTP
248978249634657PARA proteinQuickGO ontologyBLASTP
2578862589231038hypothetical proteinBLASTP
2589242602581335hypothetical proteinBLASTP
2603022624942193hypothetical proteinBLASTP
2638852650871203hypothetical proteinBLASTP
2651522662281077integraserecombinase xerDQuickGO ontologyBLASTP