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Query: NC_000921:1007519:1018568 Helicobacter pylori J99, complete genome

Start: 1018568, End: 1018849, Length: 282

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011333:1040192:1051623105162310534341812Helicobacter pylori G27 chromosome, complete genomeDNA topoisomerase I2e-36150
NC_017367:278916:2900922900922920351944Helicobacter pylori F57, complete genometopoisomerase I3e-36150
NC_010698:870312:9061329061329080661935Helicobacter pylori Shi470, complete genometopoisomerase I3e-36150
NC_017358:220900:2336282336282355621935Helicobacter pylori Cuz20 chromosome, complete genometopoisomerase I3e-36150
NC_017381:982216:989960989960990463504Helicobacter pylori 2018 chromosome, complete genomeDNA topoisomerase I9e-36148
NC_017374:974279:982005982005982508504Helicobacter pylori 2017 chromosome, complete genomeDNA topoisomerase I9e-36148
NC_017357:973392:981118981118981621504Helicobacter pylori 908 chromosome, complete genomeDNA topoisomeraseI9e-36148
NC_017361:930280:9660509660509679931944Helicobacter pylori SouthAfrica7 chromosome, complete genometopoisomerase I1e-35148