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Query: NC_000921:1007519:1034961 Helicobacter pylori J99, complete genome

Start: 1034961, End: 1035431, Length: 471

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:149276014927601493230471Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein1e-88324
NC_017366:1055319:106942310694231069893471Helicobacter pylori F32, complete genomehypothetical protein1e-88324
NC_017362:1512959:153858515385851539055471Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein1e-88324
NC_014560:1366747:139299513929951393465471Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein1e-88324
NC_011498:1391788:141316314131631413633471Helicobacter pylori P12, complete genomehypothetical protein1e-88324
NC_017063:834674:865694865694866164471Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein4e-88323
NC_017372:748097:770561770561771031471Helicobacter pylori India7 chromosome, complete genomehypothetical protein4e-88322
NC_014256:485969:508227508227508697471Helicobacter pylori B8 chromosome, complete genomehypothetical protein4e-88322
NC_017375:77142:924849248492969486Helicobacter pylori 83 chromosome, complete genomehypothetical protein1e-87321
NC_017378:1518529:153459815345981535068471Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein1e-80297
NC_017516:1755500:180943118094311809937507Neisseria meningitidis H44/76 chromosome, complete genomehypothetical protein2e-50197
NC_017515:1744500:180690518069051807411507Neisseria meningitidis M04-240196 chromosome, complete genomehypothetical protein2e-50197
NC_003112:1824196:183916618391661839672507Neisseria meningitidis MC58, complete genomehypothetical protein2e-50197
NC_017518:1843705:185871618587161859180465Neisseria meningitidis NZ-05/33 chromosome, complete genomehypothetical protein2e-50197
NC_017514:446616:492103492103492567465Neisseria meningitidis M01-240149 chromosome, complete genomehypothetical protein2e-50197
NC_017517:1807072:181982318198231820287465Neisseria meningitidis M01-240355 chromosome, complete genomehypothetical protein1e-49194
NC_008786:1553833:157599315759931576505513Verminephrobacter eiseniae EF01-2, complete genomehypothetical protein1e-21101