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Query: NC_000921:1007519:1049107 Helicobacter pylori J99, complete genome

Start: 1049107, End: 1049874, Length: 768

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011498:448000:4594054594054604691065Helicobacter pylori P12, complete genomehypothetical protein9e-109392
NC_014560:1366747:1379519137951913808291311Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein3e-1065.9
NC_017358:220900:2589242589242602581335Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein3e-0962.4
NC_017375:1498000:1514604151460415159981395Helicobacter pylori 83 chromosome, complete genomehypothetical protein5e-0961.6
NC_010698:870312:8809158809158821831269Helicobacter pylori Shi470, complete genomehypothetical protein6e-0961.2
NC_017376:57500:6747567475688691395Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein1e-0860.1
NC_011333:1040192:1077383107738310787771395Helicobacter pylori G27 chromosome, complete genomehypothetical protein1e-0860.1
NC_014555:1526775:1569202156920215705961395Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein1e-0860.1