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Query: NC_000921:1007519:1007519 Helicobacter pylori J99, complete genome

Start: 1007519, End: 1008982, Length: 1464

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017187:1305805:1318224131822413196811458Arcobacter butzleri ED-1, complete genomehypothetical protein4e-67256
NC_010519:1165418:1165418116541811672741857Haemophilus somnus 2336 chromosome, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase4e-1893.2
NC_008309:1200245:1216722121672212185781857Haemophilus somnus 129PT, complete genomepeptidyl-prolyl cis-trans isomerase D5e-1892.8
NC_016632:1049510:1062109106210910640071899Serratia symbiotica str. 'Cinara cedri' chromosome, completepeptidyl-prolyl cis-trans isomerase D1e-1481.3
NC_015388:2434922:2462598246259824644871890Desulfobacca acetoxidans DSM 11109 chromosome, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase2e-1377.8
NC_008570:2216736:2219758221975822216681911Aeromonas hydrophila subsp. hydrophila ATCC 7966, complete genomepeptidylprolyl cis-trans isomerase D2e-0861.2
NC_007484:1975322:1995112199511219970341923Nitrosococcus oceani ATCC 19707, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase2e-0860.8
NC_013446:1889500:1899634189963419015321899Comamonas testosteroni CNB-2, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase5e-0859.7
NC_014539:1839840:1859971185997118619111941Burkholderia sp. CCGE1003 chromosome 1, complete sequencePpiC-type peptidyl-prolyl cis-trans isomerase8e-0858.9
NC_011420:69843:9641296412982801869Rhodospirillum centenum SW, complete genomepeptidyl-prolyl cis-trans isomerse, putative1e-0758.5
NC_014315:1463383:1463383146338314653051923Nitrosococcus watsoni C-113 chromosome, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase1e-0758.5
NC_009943:305854:3067093067093086041896Candidatus Desulfococcus oleovorans Hxd3, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase2e-0757.4
NC_008344:669498:6701106701106720021893Nitrosomonas eutropha C91, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase3e-0757
NC_010995:2312901:2317050231705023189151866Cellvibrio japonicus Ueda107, complete genomeputative peptidyl-prolyl cis-trans isomerase D3e-0757
NC_014972:3000138:3015278301527830171581881Desulfobulbus propionicus DSM 2032 chromosome, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase5e-0756.6
NC_013960:804567:8045678045678064801914Nitrosococcus halophilus Nc4 chromosome, complete genomePpiC-type peptidyl-prolyl cis-trans isomerase7e-0755.8
NC_004129:4596040:4599284459928446011551872Pseudomonas fluorescens Pf-5, complete genomepeptidyl-prolyl cis-trans isomerase D2e-0654.3
NC_002947:2589951:2633536263353626354071872Pseudomonas putida KT2440, complete genomepeptidyl-prolyl cis-trans isomerase D, putative4e-0653.5