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Query: NC_000921:1007519:1038613 Helicobacter pylori J99, complete genome

Start: 1038613, End: 1039878, Length: 1266

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017063:834674:8737508737508750121263Helicobacter pylori ELS37 chromosome, complete genometype IV secretion system protein TrbL0651
NC_017362:1512959:1525558152555815268201263Helicobacter pylori Lithuania75 chromosome, complete genometype IV secretion system protein TrbL0649
NC_017371:1470582:1483577148357714848391263Helicobacter pylori Gambia94/24 chromosome, complete genometype IV secretion system protein TrbL0649
NC_014256:485969:4990684990685003241257Helicobacter pylori B8 chromosome, complete genometype IV secretion system protein TrbL0636
NC_014560:1366747:1401261140126114025291269Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein9e-180629
NC_017378:1518529:1542589154258915438541266Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein4e-174610
NC_017375:77142:8371683716849661251Helicobacter pylori 83 chromosome, complete genomehypothetical protein4e-173607
NC_017372:748097:7616027616027628371236Helicobacter pylori India7 chromosome, complete genomehypothetical protein8e-91334