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Query: NC_000921:1007519:1053868 Helicobacter pylori J99, complete genome

Start: 1053868, End: 1055130, Length: 1263

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014560:1366747:1374253137425313755121260Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein0662
NC_017361:1528239:1565098156509815663601263Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein0655
NC_014555:1526775:1574568157456815758301263Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein0650
NC_011498:448000:4543344543344556321299Helicobacter pylori P12, complete genomeVirB6 type IV secretion protein0638
NC_014256:485969:485969485969486682714Helicobacter pylori B8 chromosome, complete genomehypothetical protein7e-97354
NC_014256:485969:486679486679487173495Helicobacter pylori B8 chromosome, complete genomehypothetical protein9e-64244
NC_017361:930280:9359309359309371321203Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein3e-25116
NC_011333:1040192:1082440108244010836421203Helicobacter pylori G27 chromosome, complete genomehypothetical protein5e-25115
NC_017376:57500:6264362643638481206Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein8e-25115
NC_017375:1498000:1519623151962315208251203Helicobacter pylori 83 chromosome, complete genomehypothetical protein8e-25115
NC_017358:220900:2638852638852650871203Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-24114
NC_010698:870312:8761398761398773411203Helicobacter pylori Shi470, complete genomehypothetical protein2e-24114