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Query: NC_000921:1007519:1016457 Helicobacter pylori J99, complete genome

Start: 1016457, End: 1016879, Length: 423

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1030148:1034552103455210364771926Helicobacter pylori Gambia94/24 chromosome, complete genomeDNA transfer protein1e-57221
NC_017361:930280:9679779679779704752499Helicobacter pylori SouthAfrica7 chromosome, complete genomeDNA transfer protein3e-57220
NC_017376:57500:9483294832973302499Helicobacter pylori SNT49 chromosome, complete genomeDNA transfer protein3e-57219
NC_010698:870312:9080599080599105572499Helicobacter pylori Shi470, complete genomeDNA transfer protein5e-57219
NC_017358:220900:2311372311372336352499Helicobacter pylori Cuz20 chromosome, complete genomeDNA transfer protein5e-57219
NC_017367:278916:2876102876102901082499Helicobacter pylori F57, complete genomeDNA transfer protein6e-57218
NC_017379:1035464:1054184105418410566822499Helicobacter pylori Puno135 chromosome, complete genomeDNA transfer protein1e-56218
NC_014256:448710:4557574557574579102154Helicobacter pylori B8 chromosome, complete genomeprotein virB41e-22105
NC_014555:1526775:1540379154037915427482370Helicobacter pylori PeCan4 chromosome, complete genomeVirB4-like protein8e-23105
NC_000915:453958:4593334593334617562424Helicobacter pylori 26695, complete genomeVirB4 homolog7e-23105
NC_018939:454000:4593394593394617622424Helicobacter pylori 26695 chromosome, complete genomeVirB4-like protein7e-23105
NC_017361:1528239:1530624153062415330472424Helicobacter pylori SouthAfrica7 chromosome, complete genomeVirB4-like protein2e-22104
NC_014256:485969:5220375220375246132577Helicobacter pylori B8 chromosome, complete genometype IV secretion system protein VirB41e-1168.2
NC_011498:1391788:1397130139713013997062577Helicobacter pylori P12, complete genomeVirB4 type IV secretion ATPase2e-1167.8
NC_017372:748097:7931967931967957782583Helicobacter pylori India7 chromosome, complete genomeVirB4 type IV secretion ATPase2e-1167.4
NC_017371:1470582:1516315151631515188912577Helicobacter pylori Gambia94/24 chromosome, complete genomeVirB4 type IV secretion ATPase5e-1166.2