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Query: NC_000921:1007519:1022556 Helicobacter pylori J99, complete genome

Start: 1022556, End: 1023572, Length: 1017

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011498:448000:4608104608104618321023Helicobacter pylori P12, complete genomehypothetical protein9e-161566
NC_017367:278916:3150093150093160461038Helicobacter pylori F57, complete genomehypothetical protein1e-1274.3
NC_017375:1498000:1513566151356615146031038Helicobacter pylori 83 chromosome, complete genomehypothetical protein2e-1273.6
NC_017358:220900:2578862578862589231038Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein3e-1273.2
NC_014560:1366747:1380830138083013818671038Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein4e-1272.8
NC_010698:870312:8821848821848832211038Helicobacter pylori Shi470, complete genomehypothetical protein4e-1272.8
NC_017376:57500:6887068870699071038Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein6e-1272
NC_014555:1526775:1568164156816415692011038Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein1e-1170.9
NC_017361:1528239:1558781155878115597881008Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein1e-1170.9
NC_017361:930280:9420959420959431021008Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein1e-1170.9
NC_011333:1040192:1076345107634510773821038Helicobacter pylori G27 chromosome, complete genomehypothetical protein1e-1170.9
NC_017375:77142:8808088080891471068Helicobacter pylori 83 chromosome, complete genomehypothetical protein1e-1067.8
NC_017063:834674:8695498695498706011053Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein2e-1067.4
NC_017372:748097:7661877661877672391053Helicobacter pylori India7 chromosome, complete genomehypothetical protein2e-1067.4
NC_014256:485969:5037915037915048431053Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-1067.4
NC_017371:1470582:1488324148832414893761053Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein1e-1067.4
NC_017366:1055319:1073209107320910742761068Helicobacter pylori F32, complete genomehypothetical protein2e-1067
NC_017378:1518529:1538564153856415396281065Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein4e-1065.9
NC_014560:1366747:139686513968651397845981Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein8e-1064.7