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Query: NC_000921:1007519:1021498 Helicobacter pylori J99, complete genome

Start: 1021498, End: 1022304, Length: 807

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1030148:1039276103927610405231248Helicobacter pylori Gambia94/24 chromosome, complete genomecompetence protein6e-71267
NC_017376:57500:8901489014902491236Helicobacter pylori SNT49 chromosome, complete genomecompetence protein1e-69263
NC_017361:930280:9621619621619633961236Helicobacter pylori SouthAfrica7 chromosome, complete genomecompetence protein2e-69262
NC_011333:1040192:1056088105608810573231236Helicobacter pylori G27 chromosome, complete genomecompetence protein3e-69261
NC_017358:220900:2382162382162394511236Helicobacter pylori Cuz20 chromosome, complete genomecompetence protein1e-68259
NC_017367:278916:2946922946922959271236Helicobacter pylori F57, complete genomeComB3 protein3e-68258
NC_010698:870312:9022439022439034781236Helicobacter pylori Shi470, complete genomeComB3 protein6e-68257
NC_017361:1528239:1539861153986115411231263Helicobacter pylori SouthAfrica7 chromosome, complete genomeVirB10 type IV secretion protein7e-32137
NC_014555:1526775:1547587154758715488521266Helicobacter pylori PeCan4 chromosome, complete genomeVirB10 type IV secretion protein1e-27123
NC_017379:1035464:1048353104835310496181266Helicobacter pylori Puno135 chromosome, complete genomeVirB10 type IV secretion protein9e-24110
NC_011498:448000:4809874809874822521266Helicobacter pylori P12, complete genomeVirB10 type IV secretion protein6e-23107
NC_014256:448710:462746462746463504759Helicobacter pylori B8 chromosome, complete genomeDNA transformation compentancy1e-22107