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Query: NC_000921:1007519:1041145 Helicobacter pylori J99, complete genome

Start: 1041145, End: 1042158, Length: 1014

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:1481285148128514822981014Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein0650
NC_014256:485969:4967764967764977891014Helicobacter pylori B8 chromosome, complete genomehypothetical protein0644
NC_014560:1366747:140384014038401404820981Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein3e-174610
NC_000915:1044000:105360010536001054229630Helicobacter pylori 26695, complete genomehypothetical protein5e-121434
NC_000915:1044000:105437610543761054615240Helicobacter pylori 26695, complete genomehypothetical protein1e-35150
NC_017375:77142:816718167182441771Helicobacter pylori 83 chromosome, complete genomehypothetical protein3e-33142
NC_017372:748097:759698759698760345648Helicobacter pylori India7 chromosome, complete genomehypothetical protein1e-22107