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Query: NC_000921:1007519:1042390 Helicobacter pylori J99, complete genome

Start: 1042390, End: 1043367, Length: 978

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017375:77142:805048050481481978Helicobacter pylori 83 chromosome, complete genomehypothetical protein0635
NC_014560:1366747:140505314050531406033981Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein3e-174611
NC_014624:1768226:177438117743811775301921Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein2e-51202
NC_015738:2652500:267451326745132675472960Eggerthella sp. YY7918, complete genomehypothetical protein5e-34145
NC_014560:1366747:140727914072791408148870Helicobacter pylori SJM180 chromosome, complete genomepossible cell division protein5e-0858.9
NC_016023:875416:881600881600882442843Bacillus coagulans 36D1 chromosome, complete genomeHipA domain-containing protein1e-0757.8
NC_017371:1470582:147922614792261480029804Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein7e-0651.6
NC_000915:1044000:105503810550381055841804Helicobacter pylori 26695, complete genomehypothetical protein7e-0651.6
NC_014256:485969:494711494711495514804Helicobacter pylori B8 chromosome, complete genomehypothetical protein7e-0651.6
NC_017063:834674:878553878553879356804Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein7e-0651.6
NC_018939:1044000:105505510550551055858804Helicobacter pylori 26695 chromosome, complete genomehypothetical protein7e-0651.6
NC_017362:1512959:152203915220391522842804Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein7e-0651.6
NC_017179:1683199:168512816851281685997870Clostridium difficile BI1, complete genomeHipA-like protein9e-0651.6