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Query: NC_000921:1007519:1039890 Helicobacter pylori J99, complete genome

Start: 1039890, End: 1041140, Length: 1251

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:1482303148230314835801278Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein0785
NC_017063:834674:8750098750098762861278Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein0779
NC_014560:1366747:1402526140252614038031278Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein0778
NC_014256:485969:4977944977944990561263Helicobacter pylori B8 chromosome, complete genomehypothetical protein0770
NC_017378:1518529:1543851154385115451371287Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein0692
NC_017375:77142:8246382463837191257Helicobacter pylori 83 chromosome, complete genomehypothetical protein0638
NC_017372:748097:7603497603497616051257Helicobacter pylori India7 chromosome, complete genomehypothetical protein7e-143507
NC_000915:1044000:105292710529271053595669Helicobacter pylori 26695, complete genomehypothetical protein5e-115414
NC_018939:1044000:105295610529561053612657Helicobacter pylori 26695 chromosome, complete genomehypothetical protein4e-112405
NC_015674:1605923:1606647160664716078581212Helicobacter bizzozeronii CIII-1, complete genomehypothetical protein6e-72271
NC_011498:1391788:141575014157501416160411Helicobacter pylori P12, complete genomehypothetical protein4e-65248
NC_010698:870312:8773418773418787261386Helicobacter pylori Shi470, complete genomehypothetical protein5e-23108
NC_017361:930280:9371329371329385171386Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein2e-22106
NC_017375:1498000:1518238151823815196231386Helicobacter pylori 83 chromosome, complete genomehypothetical protein3e-22106
NC_017376:57500:6384863848652331386Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein4e-22106
NC_011333:1040192:1081055108105510824401386Helicobacter pylori G27 chromosome, complete genomehypothetical protein5e-22105
NC_014560:1366747:1375844137584413772441401Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein1e-1894.4
NC_014555:1526775:1572836157283615742361401Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-1893.6
NC_011498:448000:4559284559284573281401Helicobacter pylori P12, complete genomehypothetical protein3e-1893.2
NC_017361:1528239:1563366156336615647661401Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein5e-1892.4
NC_000921:1007519:1052137105213710535371401Helicobacter pylori J99, complete genomehypothetical protein6e-1892.4