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Query: NC_000921:1007519:1018979 Helicobacter pylori J99, complete genome

Start: 1018979, End: 1019965, Length: 987

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017361:930280:964934964934965920987Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein6e-153540
NC_017376:57500:917879178792773987Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein2e-152538
NC_017358:220900:235692235692236678987Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein5e-152537
NC_010698:870312:905016905016906002987Helicobacter pylori Shi470, complete genomehypothetical protein5e-152537
NC_017367:278916:292168292168293154987Helicobacter pylori F57, complete genomehypothetical protein7e-152536
NC_011333:1040192:105356410535641054550987Helicobacter pylori G27 chromosome, complete genomecompetence protein4e-151534
NC_017379:1035464:105113510511351052127993Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein7e-149526
NC_011498:448000:4837844837844849531170Helicobacter pylori P12, complete genomeVirB8 type IV secretion protein3e-74278
NC_017361:1528239:1537169153716915383321164Helicobacter pylori SouthAfrica7 chromosome, complete genomeVirB8 type IV secretion protein5e-74278
NC_014555:1526775:1544901154490115460701170Helicobacter pylori PeCan4 chromosome, complete genomeVirB8 type IV secretion protein1e-73276
NC_014256:448710:460499460499461230732Helicobacter pylori B8 chromosome, complete genomeType IV secretion system protein virB82e-71269
NC_018939:454000:4560864560864571861101Helicobacter pylori 26695 chromosome, complete genomehypothetical protein7e-50197
NC_000915:453958:4560804560804571801101Helicobacter pylori 26695, complete genomehypothetical protein7e-50197
NC_017371:1470582:1515049151504915161851137Helicobacter pylori Gambia94/24 chromosome, complete genomeVirB8 type IV secretion protein1e-35150
NC_014256:485969:5207715207715219071137Helicobacter pylori B8 chromosome, complete genomeputative VirB8 protein1e-35150
NC_011498:1391788:1399836139983614009721137Helicobacter pylori P12, complete genomeVirB8 type IV secretion protein2e-35150
NC_017372:748097:7919037919037930721170Helicobacter pylori India7 chromosome, complete genomeVirB8 type IV secretion protein2e-34146
NC_005090:1033746:105262310526231053267645Wolinella succinogenes DSM 1740, complete genomeCOMB11e-28127