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Query: NC_000921:1007519:1035401 Helicobacter pylori J99, complete genome

Start: 1035401, End: 1036204, Length: 804

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011498:1391788:141360314136031414406804Helicobacter pylori P12, complete genomehypothetical protein2e-144511
NC_017063:834674:866134866134866937804Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein3e-144510
NC_017371:1470582:149198714919871492790804Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein1e-143508
NC_014560:1366747:139343513934351394238804Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein1e-143508
NC_014256:485969:507454507454508257804Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-143508
NC_017375:77142:917149171492514801Helicobacter pylori 83 chromosome, complete genomehypothetical protein2e-139494
NC_017366:1055319:106986310698631070663801Helicobacter pylori F32, complete genomehypothetical protein1e-137489
NC_017362:1512959:153786015378601538588729Helicobacter pylori Lithuania75 chromosome, complete genomehypothetical protein4e-135480
NC_017372:748097:769812769812770591780Helicobacter pylori India7 chromosome, complete genomehypothetical protein1e-134479
NC_017378:1518529:153503815350381535829792Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein1e-133475
NC_008786:1553833:1574650157465015759931344Verminephrobacter eiseniae EF01-2, complete genomehypothetical protein3e-47188