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Query: NC_000921:1007519:1038083 Helicobacter pylori J99, complete genome

Start: 1038083, End: 1038616, Length: 534

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: This strain was isolated in 1994 in the USA from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017371:1470582:1484836148483614862691434Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein2e-98357
NC_017063:834674:8723208723208737531434Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein2e-98357
NC_014256:485969:5003215003215017541434Helicobacter pylori B8 chromosome, complete genomehypothetical protein7e-98355
NC_014560:1366747:1399831139983114012641434Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein3e-97353
NC_017378:1518529:1541159154115915425921434Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein6e-85312
NC_017372:748097:7628377628377642701434Helicobacter pylori India7 chromosome, complete genomehypothetical protein1e-84311
NC_017375:77142:849638496385616654Helicobacter pylori 83 chromosome, complete genomehypothetical protein5e-82303
NC_017358:220900:2286552286552305711917Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein1e-1892.4
NC_017367:278916:2851282851282870441917Helicobacter pylori F57, complete genomehypothetical protein3e-1891.3
NC_014256:448710:4534034534034549291527Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-1582.4
NC_018939:454000:4623214623214638441524Helicobacter pylori 26695 chromosome, complete genomehypothetical protein3e-1581.3
NC_000915:453958:4623154623154638381524Helicobacter pylori 26695, complete genomehypothetical protein3e-1581.3
NC_014555:1526775:1538240153824015397661527Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein1e-1479
NC_017361:1528239:1528539152853915300651527Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein2e-1478.2
NC_011333:1040192:1046540104654010482161677Helicobacter pylori G27 chromosome, complete genomehypothetical protein2e-0858.5
NC_017379:1035464:1057495105749510591651671Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein1e-0652.4