Pre_GI Island

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n1_4mer:GRV/n1_4mer:RV = (Global Relative Variance of OU patterns) / (Local Relative Variance of OU patterns)

n0_4mer:D = Distance between local and global OU patterns

n0_4mer:PS = Distance between 2 strands of same DNA molecule

Selected loci indicated by large D, increased GRV associated with decreased RV and moderate increase in PS

NC_004668: Enterococcus faecalis V583, complete genome

NCBI: NC_004668

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

#StartEndLengthIsland TextGRV_RVDPSNeighboursClusterSub ClusterBLASTNKey Word ConfirmationOther DB ConfirmationDownload Island
1191732*21421422483Island text1.6359223.449739.2131Neighbours325BLASTNIslandViewer 191732.gbk
2241352*26701725666Island text3.2223534.804248.8283Neighbours21BLASTN241352.gbk
329541731392418508Island text1.684224.580543.7934Neighbours21BLASTNIslandViewer 295417.gbk
4546142*57227526134Island text1.8302328.643843.1011Neighbours21BLASTN+IslandViewer PAI DB546142.gbk
51010610*103713326524Island text2.8864830.42145.5073Neighbours21BLASTN+1010610.gbk
61427674*144570618033Island text1.7802324.613930.2107Neighbours21BLASTNIslandViewer 1427674.gbk
72198027*227009972073Island text2.6071747.781839.4974Neighbours31BLASTNIslandViewer 2198027.gbk
82762464*278659224129Island text2.5660328.954747.2911Neighbours21BLASTN+2762464.gbk
92938000*296113823139Island text1.6536926.742336.3147Neighbours21BLASTN+2938000.gbk
103053119*307280919691Island text1.571125.431738.3482Neighbours21+3053119.gbk
113118500313959921100Island text1.6247228.452540.8941Neighbours325BLASTN3118500.gbk
123156247*318179425548Island text2.7288230.800844.5411Neighbours21BLASTN3156247.gbk
133184319*321199927681Island text1.6189531.845844.908Neighbours21BLASTN3184319.gbk