Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:3184319 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
318431931860911773hypothetical proteinBLASTP
31862923186969678fructose-6-phosphate aldolaseQuickGO ontologyBLASTP
31869973187353357PTS system sorbitol-specific IIA componentQuickGO ontologyBLASTP
31873783188373996PTS system sorbitol-specific IIBC componentsQuickGO ontologyBLASTP
31883903188944555PTS system sorbitol-specific IIC componentQuickGO ontologyBLASTP
31889443189429486transcriptional regulator SrlRQuickGO ontologyBLASTP
318942631912881863putative transcriptional activator SrlMQuickGO ontologyBLASTP
31913043192104801sorbitol-6-phosphate 2-dehydrogenaseQuickGO ontologyBLASTP
319227631941741899glucose-inhibited division protein AQuickGO ontologyBLASTP
319419431955911398tRNA modification GTPaseQuickGO ontologyBLASTP
31956083195712105hypothetical protein
319582432010585235cell wall surface anchor family proteinQuickGO ontologyBLASTP
32017993202668870triphosphoribosyl-dephosphocoenzyme-A synthaseQuickGO ontologyBLASTP
320267532038471173malic enzyme family proteinQuickGO ontologyBLASTP
320396532053621398oxaloacetate decarboxylaseQuickGO ontologyBLASTP
320535532058915372-5-triphosphoribosyl-3-dephospho-CoAapo- citrate lyaseQuickGO ontologyBLASTP
320588432072961413citrate lyase alpha subunitQuickGO ontologyBLASTP
32074193208306888citrate lyase beta subunitQuickGO ontologyBLASTP
32082943208602309citrate lyase gamma subunitQuickGO ontologyBLASTP
320860832096181011citrate lyase ligaseQuickGO ontologyBLASTP
32096333209767135hypothetical proteinBLASTP
320978932108741086sodium ion-translocating decarboxylase beta subunitQuickGO ontologyBLASTP
32109343211335402acetyl-CoA carboxylaseQuickGO ontologyBLASTP
32113193211681363hypothetical protein