Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:2762464 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
27624642762691228acyl carrier proteinQuickGO ontologyBLASTP
276274427637099663-oxoacyl-acyl carrier protein synthaseQuickGO ontologyBLASTP
27637252764177453transcriptional regulator MarR familyQuickGO ontologyBLASTP
27645552764785231hypothetical proteinBLASTP
276488627657768912-hydroxy-3-oxopropionate reductaseQuickGO ontologyBLASTP
276584927670721224glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
276711927681231005glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
2768316276838974tRNA-AsnQuickGO ontology
276839627685111165S ribosomal RNAQuickGO ontologyBLASTP
27686122771520290923S ribosomal RNAQuickGO ontologyBLASTP
2771696277176873tRNA-AlaQuickGO ontology
27718802773401152216S ribosomal RNAQuickGO ontologyBLASTP
27738422774096255hypothetical protein
27740742774436363hypothetical proteinBLASTP
27745102774878369general stress protein 13 putativeQuickGO ontologyBLASTP
277506227762281167aminotransferase class IIQuickGO ontologyBLASTP
27762622776468207hypothetical protein
27766332777223591peptidyl-prolyl cis-trans isomerase cyclophilin-typeQuickGO ontologyBLASTP
277742827784381011oxidoreductase pyridine nucleotide-disulfide familyQuickGO ontologyBLASTP
27784832778599117hypothetical protein
27785872779549963D-isomer specific 2-hydroxyacid dehydrogenase family proteinQuickGO ontologyBLASTP
27796142781167155423-cyclic-nucleotide 2-phosphodiesterase putativeQuickGO ontologyBLASTP
278126527825451281ABC transporter substrate-binding proteinQuickGO ontologyBLASTP
278256927838581290hypothetical proteinBLASTP
27838422784660819ABC transporter permease proteinQuickGO ontologyBLASTP
27846652785540876ABC transporter permease proteinQuickGO ontologyBLASTP
278554027865921053ABC transporter ATP-binding proteinQuickGO ontologyBLASTP