Pre_GI: OUP Neighbours

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Query: NC_004668:3118500 Enterococcus faecalis V583, complete genome

D: 28.4525

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

Number of Neighbours: 6




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandSubject Host Description Compositional Similarity Proposed Island FlowSubject Island D
NC_003210:721824Listeria monocytogenes EGD-e, complete genome76.0662 %Subject ←→ Query22.1346
NC_002973:730942Listeria monocytogenes str. 4b F2365, complete genome75.9344 %Subject ←→ Query22.6302
NC_013893:359842Staphylococcus lugdunensis HKU09-01 chromosome, complete genome75.0582 %Subject ←→ Query24.2742
NC_015603:1Lactobacillus kefiranofaciens ZW3 plasmid pWW2, complete sequence75.3922 %Subject ←→ Query26.2642
NC_008525:108687*Pediococcus pentosaceus ATCC 25745, complete genome76.4675 %Subject ←→ Query30.0765
NC_004603:1464000Vibrio parahaemolyticus RIMD 2210633 chromosome I, complete75.288 %Subject ←→ Query31.3716