Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:1427674 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14276741428033360hypothetical protein
14280201428496477hypothetical proteinBLASTP
142849314295301038hypothetical proteinBLASTP
14295461429944399hypothetical proteinBLASTP
14299971430329333hypothetical proteinBLASTP
14303101430510201hypothetical proteinBLASTP
143051314356785166hypothetical proteinBLASTP
14356781436235558LysM domain proteinQuickGO ontologyBLASTP
14362451436607363hypothetical proteinBLASTP
14366081437438831hypothetical proteinBLASTP
14374381437770333hypothetical proteinBLASTP
14377701438117348hypothetical proteinBLASTP
143811014392641155hypothetical proteinBLASTP
14392481439877630hypothetical proteinBLASTP
143989614415391644hypothetical proteinBLASTP
14415611441995435hypothetical proteinBLASTP
14419951442123129hypothetical proteinBLASTP
14421281442484357hypothetical proteinBLASTP
14424811442678198hypothetical protein
144273714438431107endolysinQuickGO ontologyBLASTP
1443937144401074tRNA-MetQuickGO ontology
14441461444550405hypothetical protein
144454314457061164hypothetical protein