Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:546142 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5444045461581755ABC transporter ATP-binding proteinpermease proteinQuickGO ontologyBLASTP
5461425478841743ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
548407548676270ribosomal protein S14QuickGO ontologyBLASTP
548691548870180ribosomal protein L32QuickGO ontologyBLASTP
548902549279378hypothetical proteinBLASTP
54930054944915050S ribosomal protein L33QuickGO ontologyBLASTP
549473549637165hypothetical proteinBLASTP
5499765515261551polysaccharide deacetylase family proteinQuickGO ontologyBLASTP
559056559430375hypothetical protein
5594595606371179ISEf1 transposaseQuickGO ontologyBLASTP
562902563132231hypothetical protein
563269563892624transcriptional regulator TetR familyQuickGO ontologyBLASTP
563900564544645transcriptional regulator TetR familyQuickGO ontologyBLASTP
566493566978486hypothetical protein
567357567935579gls24 proteinQuickGO ontologyBLASTP
568182568742561hypothetical protein
569460569927468Dps family proteinQuickGO ontologyBLASTP
570062570595534ParB-like nuclease domain proteinQuickGO ontologyBLASTP
570582571007426hypothetical protein
5710045722751272hypothetical proteinBLASTP