Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:3156247 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
315624731572571011hypothetical proteinBLASTP
315752631600212496ATP-dependent Clp protease ATP-binding subunit ClpCQuickGO ontologyBLASTP
31600243160491468transcriptional regulator CtsRQuickGO ontologyBLASTP
316079631619831188cystathionine gamma-synthase putativeQuickGO ontologyBLASTP
316200331633101308PTS system IIC componentQuickGO ontologyBLASTP
31634563164313858phosphosugar-binding transcriptional regulator putativeQuickGO ontologyBLASTP
3164359316443274tRNA-ProQuickGO ontology
3164522316459574tRNA-ArgQuickGO ontologyBLASTP
3164610316469586tRNA-LeuQuickGO ontologyBLASTP
3164711316478272tRNA-GlyQuickGO ontology
3164787316486276tRNA-ThrQuickGO ontologyBLASTP
3164869316495082tRNA-LeuQuickGO ontology
3164967316503973tRNA-LysQuickGO ontologyBLASTP
3165046316511873tRNA-ValQuickGO ontologyBLASTP
316513331652481165S ribosomal RNAQuickGO ontologyBLASTP
31653493168257290923S ribosomal RNAQuickGO ontologyBLASTP
31685163170037152216S ribosomal RNAQuickGO ontologyBLASTP
3170403317048684hypothetical protein
31707113171400690DNA-binding response regulatorQuickGO ontologyBLASTP
317139031725711182sensor histidine kinaseQuickGO ontologyBLASTP
317290631741771272seryl-tRNA synthetaseQuickGO ontologyBLASTP
317438931758701482inositol-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
317602831777101683hypothetical proteinBLASTP
31778773178566690hypothetical protein
317867531797901116GTP-binding protein GTP1OBG familyQuickGO ontologyBLASTP
31798473180032186hypothetical proteinBLASTP
31801503181040891chromosome partitioning protein ParB familyQuickGO ontologyBLASTP
31810333181794762ATPase ParA familyQuickGO ontologyBLASTP