Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:3118500 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
31187493118946198hypothetical protein
311913631228943759hypothetical proteinBLASTP
31234903123633144hypothetical proteinBLASTP
312382331257601938hypothetical proteinBLASTP
31257963126731936hypothetical proteinBLASTP
312709331308903798hypothetical proteinBLASTP
31308773131239363cell wall surface anchor family proteinQuickGO ontologyBLASTP
3131627313257494814-dihydroxy-2-naphthoate octaprenyltransferaseQuickGO ontologyBLASTP
313258831336551068thiamin biosynthesis lipoprotein ApbE putativeQuickGO ontologyBLASTP
31339103134839930pheromone cAD1 precursor lipoproteinQuickGO ontologyBLASTP
313511631370621947oxidoreductase pyridine nucleotide-disulfide familyQuickGO ontologyBLASTP
31372803137702423hypothetical proteinBLASTP
31377143138271558hypothetical proteinBLASTP
31383093139295987heptaprenyl diphosphate synthase component II putativeQuickGO ontologyBLASTP