Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:1010610 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
101061010123671758pyruvate kinaseQuickGO ontologyBLASTP
10127411013310570hypothetical proteinBLASTP
1013367101354618050S ribosomal protein L32QuickGO ontologyBLASTP
1013751101517214226-phosphogluconate dehydrogenaseQuickGO ontologyBLASTP
10153301016016687DNA-binding response regulatorQuickGO ontologyBLASTP
101602710175351509sensor histidine kinaseQuickGO ontologyBLASTP
10177911017955165hypothetical protein
10181871019708152216S ribosomal RNAQuickGO ontologyBLASTP
1019820101989273tRNA-AlaQuickGO ontology
10200691022977290923S ribosomal RNAQuickGO ontologyBLASTP
102307810231931165S ribosomal RNAQuickGO ontologyBLASTP
1023200102327374tRNA-AsnQuickGO ontology
1023317102340589tRNA-SerQuickGO ontologyBLASTP
1023423102349472tRNA-GluQuickGO ontologyBLASTP
1023522102359473tRNA-ValQuickGO ontologyBLASTP
1023605102368076tRNA-AspQuickGO ontology
1023726102379873tRNA-PheQuickGO ontology
1023804102388481tRNA-TyrQuickGO ontology
1023889102396274tRNA-TrpQuickGO ontology
1023999102407173tRNA-HisQuickGO ontology
1024086102415772tRNA-GlnQuickGO ontology
1024183102425371tRNA-CysQuickGO ontology
1024267102435084tRNA-LeuQuickGO ontologyBLASTP
10249271025736810ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
102579510275521758ABC transporter permease proteinQuickGO ontologyBLASTP
10280971028609513tunicamycin resistance protein putativeQuickGO ontologyBLASTP
1028673102876896hypothetical protein
102887810304761599Mn2Fe2 transporter NRAMP familyQuickGO ontologyBLASTP
10304761030901426universal stress protein familyQuickGO ontologyBLASTP
103095610326261671hypothetical proteinBLASTP
103300710346681662pheromone binding proteinQuickGO ontologyBLASTP
103469610359191224cytosine deaminaseQuickGO ontologyBLASTP
103591610371331218cytosine deaminaseQuickGO ontologyBLASTP