Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:191732 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
19173219220247130S ribosomal protein S7QuickGO ontologyBLASTP
1922861943672082elongation factor EF-2QuickGO ontologyBLASTP
1945181957051188elongation factor TuQuickGO ontologyBLASTP
195887196711825phosphomethylpyrimidine kinase putativeQuickGO ontologyBLASTP
1969831981491167cyclopropane-fatty-acyl-phospholipid synthaseQuickGO ontologyBLASTP
198498198806309ribosomal protein S10QuickGO ontologyBLASTP
19882819945763050S ribosomal protein L3QuickGO ontologyBLASTP
19948320010662450S ribosomal protein L4QuickGO ontologyBLASTP
200106200396291ribosomal protein L23QuickGO ontologyBLASTP
20043620126683150S ribosomal protein L2QuickGO ontologyBLASTP
20130920158727930S ribosomal protein S19QuickGO ontologyBLASTP
201609201956348ribosomal protein L22QuickGO ontologyBLASTP
20202320267965730S ribosomal protein S3QuickGO ontologyBLASTP
20268220311643550S ribosomal protein L16QuickGO ontologyBLASTP
203106203294189ribosomal protein L29QuickGO ontologyBLASTP
20331820358426730S ribosomal protein S17QuickGO ontologyBLASTP
203642204010369ribosomal protein L14QuickGO ontologyBLASTP
20404620435731250S ribosomal protein L24QuickGO ontologyBLASTP
204383204922540ribosomal protein L5QuickGO ontologyBLASTP
20494120512618630S ribosomal protein S14QuickGO ontologyBLASTP
205162205560399ribosomal protein S8QuickGO ontologyBLASTP
20559220612853750S ribosomal protein L6QuickGO ontologyBLASTP
20628920664535750S ribosomal protein L18QuickGO ontologyBLASTP
206666207166501ribosomal protein S5QuickGO ontologyBLASTP
207181207360180ribosomal protein L30QuickGO ontologyBLASTP
20740820784844150S ribosomal protein L15QuickGO ontologyBLASTP
2078492091471299preprotein translocase SecYQuickGO ontologyBLASTP
209234209884651adenylate kinaseQuickGO ontologyBLASTP
210095210313219translation initiation factor IF-1QuickGO ontologyBLASTP
21034621046211750S ribosomal protein L36QuickGO ontologyBLASTP
21048221084736630S ribosomal protein S13QuickGO ontologyBLASTP
21087521126439030S ribosomal protein S11QuickGO ontologyBLASTP
211345212283939DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
212357212740384ribosomal protein L17QuickGO ontologyBLASTP
2130152142141200hypothetical proteinBLASTP