Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:2938000 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
29381392938702564peptide deformylaseQuickGO ontologyBLASTP
29387492939525777hydrolase haloacid dehalogenase-like familyQuickGO ontologyBLASTP
29395352940188654hypothetical proteinBLASTP
29402602941063804formatenitrite transporter family proteinQuickGO ontologyBLASTP
2941388294199961230S ribosomal protein S4QuickGO ontologyBLASTP
29420362942140105hypothetical protein
29421592942707549BioY family proteinQuickGO ontologyBLASTP
29427692943305537signal peptidase IQuickGO ontologyBLASTP
294336029472443885hypothetical proteinBLASTP
294773929520194281hypothetical proteinBLASTP
29520062952368363cell wall surface anchor family proteinQuickGO ontologyBLASTP
29527342953345612hypothetical proteinBLASTP
29533802953937558acetyltransferase GNAT familyQuickGO ontologyBLASTP
295402329552431221peptidase TQuickGO ontologyBLASTP
295526529569081644pheromone binding proteinQuickGO ontologyBLASTP
29574852958438954iron compound ABC transporter substrate-binding proteinQuickGO ontologyBLASTP
29584772959232756iron compound ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
29592292960194966iron compound ABC transporter permease proteinQuickGO ontologyBLASTP
29601912961138948iron compound ABC transporter permease proteinQuickGO ontologyBLASTP