Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:241352 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
241352241897546hypoxanthine-guanine phosphoribosyltransferaseQuickGO ontologyBLASTP
2419912441472157cell division protein FtsHQuickGO ontologyBLASTP
244309245205897chaperonin 33 kDaQuickGO ontologyBLASTP
245217246215999zinc-binding TIM-barrel protein nifR3 family putativeQuickGO ontologyBLASTP
2463092478051497lysyl-tRNA synthetaseQuickGO ontologyBLASTP
248466249987152216S ribosomal RNAQuickGO ontologyBLASTP
250246253154290923S ribosomal RNAQuickGO ontologyBLASTP
2532552533701165S ribosomal RNAQuickGO ontologyBLASTP
25338525345773tRNA-ValQuickGO ontologyBLASTP
25346425353673tRNA-LysQuickGO ontologyBLASTP
25355325363482tRNA-LeuQuickGO ontology
25364125371676tRNA-ThrQuickGO ontologyBLASTP
25372125379272tRNA-GlyQuickGO ontology
25380825389386tRNA-LeuQuickGO ontologyBLASTP
25390825398174tRNA-ArgQuickGO ontologyBLASTP
25399325406674tRNA-ProQuickGO ontology
25408025415273tRNA-AlaQuickGO ontology
25417625424974tRNA-MetQuickGO ontology
25427025434374tRNA-MetQuickGO ontologyBLASTP
25437725446690tRNA-SerQuickGO ontologyBLASTP
25450025457374tRNA-MetQuickGO ontology
25461225468877tRNA-AspQuickGO ontologyBLASTP
25469025476071tRNA-GlyQuickGO ontologyBLASTP
25477025484374tRNA-IleQuickGO ontology
25485825492972tRNA-GluQuickGO ontologyBLASTP
25494225503190tRNA-SerQuickGO ontologyBLASTP
25506525513874tRNA-MetQuickGO ontology
25518725526074tRNA-AspQuickGO ontologyBLASTP
25526625533873tRNA-PheQuickGO ontologyBLASTP
25535325542371tRNA-GlyQuickGO ontologyBLASTP
25543725551074tRNA-IleQuickGO ontology
25552125560888tRNA-SerQuickGO ontologyBLASTP
25562425569572tRNA-GluQuickGO ontologyBLASTP
2568532587511899PTS system beta-glucoside-specific IIABC componentQuickGO ontologyBLASTP
2587752602051431glycosyl hydrolase family 1QuickGO ontologyBLASTP
2603282617941467glycosyl hydrolase family 1QuickGO ontologyBLASTP
261815262633819phosphoglycerate mutase family proteinQuickGO ontologyBLASTP
262771263514744hypothetical proteinBLASTP
263532264098567ada regulatory protein putativeQuickGO ontologyBLASTP
264296264727432methylated-DNA--protein-cysteine S-methyltransferaseQuickGO ontologyBLASTP
264740265252513DNA-3-methyladenine glycosylase IQuickGO ontologyBLASTP
265265265939675HD domain proteinQuickGO ontologyBLASTP
266082267017936cation efflux family proteinQuickGO ontologyBLASTP