Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:3053119 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
30531193053616498RNA polymerase sigma-70 factor ECF subfamilyQuickGO ontologyBLASTP
305373730551881452hypothetical proteinBLASTP
30551723055657486hypothetical proteinBLASTP
305575930568351077cell wall surface anchor family protein putativeQuickGO ontologyBLASTP
30569483057706759hypothetical proteinBLASTP
30577073058507801hypothetical proteinBLASTP
30585123059246735hypothetical proteinBLASTP
30592033059592390cell wall surface anchor family proteinQuickGO ontology
305961230642764665hypothetical proteinBLASTP
30643833064517135hypothetical protein
306483830658511014lipase putativeQuickGO ontologyBLASTP
30660173066562546isochorismatase family proteinQuickGO ontologyBLASTP
30667673067450684antiholin-like protein LrgBQuickGO ontologyBLASTP
30674473067866420murein hydrolase regulator LrgAQuickGO ontologyBLASTP
30680183068746729response regulatorQuickGO ontologyBLASTP
306872730704961770sensor histidine kinaseQuickGO ontologyBLASTP
30705883071406819lipoprotein YaeC familyQuickGO ontologyBLASTP
30714193072090672ABC transporter permease proteinQuickGO ontologyBLASTP
30720873072809723ABC transporter ATP-binding proteinQuickGO ontologyBLASTP