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Query: NC_004668:3053119:3067447 Enterococcus faecalis V583, complete genome

Start: 3067447, End: 3067866, Length: 420

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017316:2581781:259714325971432597562420Enterococcus faecalis OG1RF chromosome, complete genomemurein hydrolase regulator LrgA3e-48189
NC_003366:2266757:226768722676872268064378Clostridium perfringens str. 13, complete genomehypothetical protein4e-0650.1
NC_008261:2481500:248153124815312481908378Clostridium perfringens ATCC 13124, complete genomelrgA family protein4e-0650.1
NC_008262:2150944:215094421509442151321378Clostridium perfringens SM101, complete genomelrgA family protein4e-0650.1
NC_019435:747162:762545762545762949405Lactococcus lactis subsp. cremoris UC509.9, complete genomeMurein hydrolase exporter6e-0649.3
NC_008527:740060:755441755441755845405Lactococcus lactis subsp. cremoris SK11, complete genomePutative effector of murein hydrolase LrgA6e-0649.3
NC_009004:1770497:177623317762331776637405Lactococcus lactis subsp. cremoris MG1363, complete genomeLrgA family protein7e-0649.3