Pre_GI Gene

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Host: NC_004668 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004668:295417 Enterococcus faecalis V583, complete genome

Host Lineage: Enterococcus faecalis; Enterococcus; Enterococcaceae; Lactobacillales; Firmicutes; Bacteria

General Information: This strain is one of the first vancomycin-resistant strains isolated. This isolate came from a blood culture derived from a chronically-infected patient in 1987 from Barnes Hospital in St. Louis, Missouri, USA. This strain was found to lack the cytolysin gene and a surface adhesin, Esp, that contributes to urinary tract infections. Mobile genetic elements make up one quarter of the genome. This genera consists of organisms typically found in the intestines of mammals, although through fecal contamination they can appear in sewage, soil, and water. They cause a number of infections that are becoming increasingly a problem due to the number of antibiotic resistance mechanisms these organisms have picked up. Both Enterococcus faecalis and Enterococcus faecium cause similar diseases in humans, and are mainly distinguished by their metabolic capabilities. This opportunistic pathogen can cause urinary tract infections, bacteremia (bacteria in the blood), and infective endocarditis (inflammation of the membrane surrounding the heart), similar to infections caused by Enterococcus faecium. Hospital-acquired infections from this organism are on the rise due to the emergence of antiobiotic resistance strains. Enterococcus faecalis produces a cytolysin toxin that is encoded on various mobile genetic elements, pathogenicity islands, and conjugative plasmids. The cytolysin aids in pathogenesis, possibly by causing destruction of cells such as erythrocytes, which allows access to new nutrients for the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
295191295442252hypothetical proteinBLASTP
295417295608192transcriptional regulator CroCI familyQuickGO ontology
295624296103480hypothetical protein
2961062972781173hypothetical proteinBLASTP
297278297526249hypothetical protein
297542297871330hypothetical protein
297898298473576hypothetical proteinBLASTP
298526298747222hypothetical protein
298734299282549hypothetical protein
2992793012401962DNA polymerase putativeQuickGO ontologyBLASTP
301253301492240hypothetical protein
301511301813303hypothetical proteinBLASTP
3020153044532439hypothetical proteinBLASTP
304826305146321hypothetical proteinBLASTP
3051533065261374SNF2 domain proteinQuickGO ontologyBLASTP
306700307140441hypothetical protein
307231307680450hypothetical proteinBLASTP
3076773089331257conserved hypothetical protein TIGR01630QuickGO ontology
3089483104801533portal proteinQuickGO ontologyBLASTP
3104103118731464minor head proteinQuickGO ontologyBLASTP
311866312069204hypothetical protein
312127312336210hypothetical protein
312473313045573scaffold proteinQuickGO ontologyBLASTP
313061313924864major capsid protein putativeQuickGO ontologyBLASTP