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Query: NC_017297:3594000:3606048 Clostridium botulinum F str. 230613 chromosome, complete genome

Start: 3606048, End: 3606965, Length: 918

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009699:3581376:360743336074333608350918Clostridium botulinum F str. Langeland chromosome, complete genome8-oxoguanine DNA glycosylase6e-179626
NC_009697:3463736:348978734897873490704918Clostridium botulinum A str. ATCC 19397 chromosome, complete8-oxoguanine DNA glycosylase1e-178625
NC_009495:3502000:351379935137993514716918Clostridium botulinum A str. ATCC 3502 chromosome, complete genome8-oxoguanine DNA glycosylase1e-178625
NC_012563:3729817:375587337558733756790918Clostridium botulinum A2 str. Kyoto, complete genomeputative 8-oxoguanine DNA glycosylase4e-176617
NC_010520:3580000:359100235910023591919918Clostridium botulinum A3 str. Loch Maree, complete genomeputative 8-oxoguanine DNA glycosylase4e-172603
NC_008593:2136759:214821121482112149089879Clostridium novyi NT, complete genome8-oxoguanine-DNA-glycosylase, putative1e-120432
NC_015425:2389400:240477224047722405650879Clostridium botulinum BKT015925 chromosome, complete genomeputative 8-oxoguanine DNA glycosylase2e-117421
NC_014393:3650957:365590336559033656778876Clostridium cellulovorans 743B chromosome, complete genomeDNA-(apurinic or apyrimidinic site) lyase2e-111402
NC_021182:1473535:148750414875041488382879Clostridium pasteurianum BC1, complete genome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase4e-110397
NC_004557:2552418:255790725579072558842936Clostridium tetani E88, complete genome8-oxoguanine DNA glycosylase1e-106386
NC_008262:2498000:250322425032242504162939Clostridium perfringens SM101, complete genome8-oxoguanine DNA glycosylase, putative2e-104379
NC_010674:370629:386582386582387508927Clostridium botulinum B str. Eklund 17B, complete genome8-oxoguanine DNA glycosylase1e-101369
NC_010723:371741:381973381973382899927Clostridium botulinum E3 str. Alaska E43, complete genome8-oxoguanine DNA glycosylase7e-100363
NC_009617:385000:392811392811393740930Clostridium beijerinckii NCIMB 8052 chromosome, complete genome8-oxoguanine DNA glycosylase5e-99360
NC_020291:491000:508306508306509232927Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase8e-96350
NC_018664:287769:297133297133298017885Clostridium acidurici 9a chromosome, complete genome8-oxoguanine DNA glycosylase2e-81302
NC_015275:3594890:361343036134303614326897Clostridium lentocellum DSM 5427 chromosome, complete genomeDNA-(apurinic or apyrimidinic site) lyase1e-58227
NC_016630:864601:895181895181896071891Filifactor alocis ATCC 35896 chromosome, complete genome3-methyladenine DNA glycosylase3e-57222
NC_019977:1996414:201937920193792020218840Methanomethylovorans hollandica DSM 15978, complete genome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase7e-36150
NC_007955:1198994:121547612154761216315840Methanococcoides burtonii DSM 6242, complete genome8-oxoguanine DNA glycosylase-like protein3e-35149
NC_012785:20454:400804008040973894Kosmotoga olearia TBF 19.5.1, complete genome8-oxoguanine DNA glycosylase domain protein6e-32137
NC_016024:1472421:1484493148449314855511059Candidatus Chloracidobacterium thermophilum B chromosome chromosome3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase6e-27121
NC_012029:1525929:152916915291691530095927Halorubrum lacusprofundi ATCC 49239 chromosome 1, complete genome8-oxoguanine DNA glycosylase domain protein1e-26120
NC_011026:2624775:263091326309132631884972Chloroherpeton thalassium ATCC 35110, complete genome8-oxoguanine DNA glycosylase domain protein6e-1994.7
NC_002932:937157:946201946201947166966Chlorobium tepidum TLS, complete genome8-oxoguanine DNA glycosylase, putative3e-1685.9