Pre_GI Gene

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Host: NC_004557 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_004557:2552418 Clostridium tetani E88, complete genome

Host Lineage: Clostridium tetani; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a virulent nonsporulating variant of strain Massachusetts used in vaccine production. Causes tetanus. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism causes tetanus (lockjaw) in humans. At the tissue level, the bacterium then releases an exotoxin called tetanospasmin that causes certain nervous system irregularities by means of retrograde tramsmission through neurons to the brain. If nervous impulses cannot be checked by normal inhibitory mechanisms, it produces the generalized muscular spasms characteristic of tetanus.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
255241825540491632chaperonin GroELQuickGO ontologyBLASTP
25546832555321639membrane spanning proteinQuickGO ontologyBLASTP
25553252556050726putative membrane-associated alkaline phosphataseQuickGO ontologyBLASTP
255621925577031485periplasmic Fe hydrogenase 1QuickGO ontologyBLASTP
255790725588429368-oxoguanine DNA glycosylaseQuickGO ontologyBLASTP
255889625603201425glutamate synthase NADPH small chainQuickGO ontologyBLASTP
25602902561180891dihydroorotate dehydrogenase electron transfer subunitQuickGO ontologyBLASTP
256133925625081170NADPH-dependent butanol dehydrogenaseQuickGO ontologyBLASTP
256271825635668493-hydroxybutyryl-CoA dehydrogenaseQuickGO ontologyBLASTP
256359625646061011electron transfer flavoprotein alpha-subunitQuickGO ontologyBLASTP
25646272565406780electron transfer flavoprotein beta-subunitQuickGO ontologyBLASTP
256542425665631140butyryl-coA dehydrogenaseQuickGO ontologyBLASTP
25665772567359783enoyl-CoA hydrataseQuickGO ontologyBLASTP
25676282568263636redox-sensing transcriptional repressor RexQuickGO ontologyBLASTP
256842125703461926ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
257059125716251035transporterQuickGO ontologyBLASTP
25716692572481813pyrroline-5-carboxylate reductaseQuickGO ontologyBLASTP
257249825735201023O-sialoglycoprotein endopeptidaseQuickGO ontologyBLASTP
25736512574319669hypothetical proteinBLASTP