Pre_GI Gene

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Host: NC_010520 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010520:3580000 Clostridium botulinum A3 str. Loch Maree, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A3 str. Loch Maree was isolated from duck liver paste during a botulism outbreak at a hotel in the Scottish highlands in 1922. This was the first and worst outbreak of botulism in the United Kingdom (UK). This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
358000835811981191branched-chain amino acid transport system II carrier proteinQuickGO ontologyBLASTP
358165335831851533GMP synthaseQuickGO ontologyBLASTP
358319835846521455inosine-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
35850933585842750PP-loop family proteinQuickGO ontologyBLASTP
358592135875461626chaperonin GroELQuickGO ontologyBLASTP
35875763587863288chaperonin 10 kDaQuickGO ontologyBLASTP
35881793588823645integral membrane protein TIGR01906QuickGO ontologyBLASTP
35888183589030213putative integral membrane proteinQuickGO ontologyBLASTP
358933635908291494Fe hydrogenaseQuickGO ontologyBLASTP
35910023591919918putative 8-oxoguanine DNA glycosylaseQuickGO ontologyBLASTP
359207035934551386glutamate synthase NADPH homotetramericQuickGO ontologyBLASTP
35934553594345891oxidoreductase NAD-bindingQuickGO ontologyBLASTP
35945763595208633transcriptional regulator Rex familyQuickGO ontologyBLASTP
359540835973301923putative drug resistance ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
35976703598434765DNA-binding response regulator LytTr familyQuickGO ontologyBLASTP
359843536000691635sensor histidine kinaseQuickGO ontologyBLASTP
360031236017301419carbon starvation protein CstAQuickGO ontologyBLASTP
360178136047082928putative peptidaseQuickGO ontologyBLASTP