Pre_GI Gene

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Host: NC_008262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_008262:2498000 Clostridium perfringens SM101, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This is a enterotoxin-producing food poisoning strain. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
24980462498789744signal peptidase type IVQuickGO ontologyBLASTP
24990642499486423Prepilin peptidase dependent protein A precursorQuickGO ontology
25013632501647285chaperonin 10 kDaQuickGO ontologyBLASTP
25020182502668651integral membrane proteinQuickGO ontologyBLASTP
25027952503100306hypothetical proteinBLASTP
250322425041629398-oxoguanine DNA glycosylase putativeQuickGO ontologyBLASTP
25041722504576405hypothetical proteinBLASTP
25048192505319501signal peptidase IQuickGO ontologyBLASTP
250546125071611701ABC transporter ATP binding protein-like protein lin0829QuickGO ontologyBLASTP
250742025082688493-hydroxybutyryl-CoA dehydrogenaseQuickGO ontologyBLASTP
2508382250938910083-hydroxybutyryl-CoA dehydrogenaseQuickGO ontologyBLASTP
25094112510190780electron transfer flavoprotein beta-subunitQuickGO ontologyBLASTP
251020925113481140butyryl-CoA dehydrogenaseQuickGO ontologyBLASTP
251139525121777833-hydroxybutyryl-CoA dehydrataseQuickGO ontologyBLASTP
25124362513074639DNA-binding proteinQuickGO ontologyBLASTP
251354125157572217zinc-transporting atpaseQuickGO ontologyBLASTP
25157732516132360transcription repressor smtb-like protein PAB0625QuickGO ontologyBLASTP
25167092516918210GntR family transcription regulatorQuickGO ontologyBLASTP
25170022517580579hypothetical proteinBLASTP
25179612518527567hypothetical proteinBLASTP
251875625198261071mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
252006325214421380beta-glucosidase aQuickGO ontologyBLASTP