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Query: NC_008261:2957354:2962864 Clostridium perfringens ATCC 13124, complete genome

Start: 2962864, End: 2963172, Length: 309

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: The species type strain, originally isolated from a human gas gangrene patient. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Known opportunistic toxin-producing pathogens in animals and humans. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. C. perfringens have been developed and the species became a model organism in clostridial genetic studies. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008262:2598920:260525226052522605560309Clostridium perfringens SM101, complete genomehypothetical protein6e-47186
NC_003366:2731995:274021927402192740527309Clostridium perfringens str. 13, complete genomehypothetical protein8e-47185
NC_010723:223935:263394263394263675282Clostridium botulinum E3 str. Alaska E43, complete genomehypothetical protein3e-1373.6
NC_021182:4557608:456430145643014564579279Clostridium pasteurianum BC1, complete genomehypothetical protein8e-0855.8
NC_020134:2801199:281079028107902811080291Clostridium stercorarium subsp. stercorarium DSM 8532, completehypothetical protein1e-0652.4
NC_012658:3778822:378602137860213786302282Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein3e-0650.8
NC_014209:1910109:193252319325231932789267Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,hypothetical protein4e-0650.1
NC_009495:3688138:369533736953373695627291Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein4e-0650.1
NC_012563:3956500:396324639632463963527282Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-0650.1
NC_010516:3759136:376633537663353766616282Clostridium botulinum B1 str. Okra, complete genomehypothetical protein4e-0650.1
NC_009697:3659834:367132636713263671607282Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-0650.1
NC_009698:3553365:356843535684353568716282Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein4e-0650.1
NC_009699:3790917:379811637981163798397282Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein4e-0650.1
NC_017297:3787191:379673037967303797011282Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein4e-0650.1
NC_009633:4563877:456590945659094566193285Alkaliphilus metalliredigens QYMF chromosome, complete genomehypothetical protein7e-0649.3
NC_013921:1977444:199985019998502000116267Thermoanaerobacter italicus Ab9 chromosome, complete genomehypothetical protein8e-0648.9