Pre_GI Gene

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Host: NC_009495 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009495:3688138 Clostridium botulinum A str. ATCC 3502 chromosome, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a well-studied Hall strain that produces type A toxin. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. Some species are capable of producing organic solvents (acetone, ethanol, etc,), molecular hydrogen and other useful compounds. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3688138368857543850S ribosomal protein L13QuickGO ontologyBLASTP
36886963689436741tRNA pseudouridine synthase AQuickGO ontologyBLASTP
36894363690239804cobalt ABC transporter permeaseQuickGO ontologyBLASTP
36902363691102867cobalt transporter ATP-binding subunitQuickGO ontologyBLASTP
36910873691944858cobalt transporter ATP-binding subunitQuickGO ontologyBLASTP
3692026369236734250S ribosomal protein L17QuickGO ontologyBLASTP
36924113693358948DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
3693426369404662130S ribosomal protein S4QuickGO ontologyBLASTP
3694081369447939930S ribosomal protein S11QuickGO ontologyBLASTP
3694497369486837230S ribosomal protein S13QuickGO ontologyBLASTP
3694981369509411450S ribosomal protein L36QuickGO ontologyBLASTP
36951113695329219translation initiation factor IF-1QuickGO ontologyBLASTP
36953373695627291hypothetical proteinBLASTP
36956333696382750methionine aminopeptidaseQuickGO ontologyBLASTP
36963823697032651adenylate kinaseQuickGO ontologyBLASTP
369705636983331278preprotein translocase subunit SecYQuickGO ontologyBLASTP
3698334369877444150S ribosomal protein L15QuickGO ontologyBLASTP
3698794369897318050S ribosomal protein L30QuickGO ontologyBLASTP
3698987369948449830S ribosomal protein S5QuickGO ontologyBLASTP
3699502369986136050S ribosomal protein L18QuickGO ontologyBLASTP
3699880370042254350S ribosomal protein L6QuickGO ontologyBLASTP
3700446370084439930S ribosomal protein S8QuickGO ontologyBLASTP
3700874370105918630S ribosomal protein S14QuickGO ontologyBLASTP
3701076370161854350S ribosomal protein L5QuickGO ontologyBLASTP
3701641370195831850S ribosomal protein L24QuickGO ontologyBLASTP
3701982370235036950S ribosomal protein L14QuickGO ontologyBLASTP
3702385370263925530S ribosomal protein S17QuickGO ontologyBLASTP
3702661370287321350S ribosomal protein L29QuickGO ontologyBLASTP
3702863370330644450S ribosomal protein L16QuickGO ontologyBLASTP
3703324370399567230S ribosomal protein S3QuickGO ontologyBLASTP
3704013370434833650S ribosomal protein L22QuickGO ontologyBLASTP
3704370370465428530S ribosomal protein S19QuickGO ontologyBLASTP
3704724370555783450S ribosomal protein L2QuickGO ontologyBLASTP
3705612370590529450S ribosomal protein L23QuickGO ontologyBLASTP
3705905370652562150S ribosomal protein L4QuickGO ontologyBLASTP
3706550370717963050S ribosomal protein L3QuickGO ontologyBLASTP
3707269370757730930S ribosomal protein S10QuickGO ontologyBLASTP
370797437091671194elongation factor TuQuickGO ontologyBLASTP
370920737112762070elongation factor GQuickGO ontologyBLASTP
3711342371181247130S ribosomal protein S7QuickGO ontologyBLASTP
3711973371235037830S ribosomal protein S12QuickGO ontologyBLASTP
37124263712665240ribosomal protein L7Ae family proteinQuickGO ontologyBLASTP
371279037163263537DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
371634737200453699DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP
3720310372068137250S ribosomal protein L7L12QuickGO ontologyBLASTP
3720728372122850150S ribosomal protein L10QuickGO ontologyBLASTP
3721430372211969050S ribosomal protein L1QuickGO ontologyBLASTP
3722176372260142650S ribosomal protein L11QuickGO ontologyBLASTP
37226723723196525transcription antitermination protein NusGQuickGO ontologyBLASTP
37232433723470228preprotein translocase subunit SecEQuickGO ontologyBLASTP
3723520372366915050S ribosomal protein L33QuickGO ontologyBLASTP
372387137250641194elongation factor TuQuickGO ontologyBLASTP
3725147372522276tRNA-ThrQuickGO ontologyBLASTP
37253803725952573RNA polymerase factor sigma-70QuickGO ontologyBLASTP
37260953726604510hypothetical proteinBLASTP
37266073727380774TrmH family RNA methyltransferaseQuickGO ontologyBLASTP