Pre_GI Gene

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Host: NC_009697 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_009697:3659834 Clostridium botulinum A str. ATCC 19397 chromosome, complete

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum A ATCC 19397 (NCTC 4587, NCTC 7272) is a stock, type A toxin-producing, laboratory strain of known toxicity. Produces botulinum, one of the most potent toxins known. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin. Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
36598343660676843fumarate hydrataseQuickGO ontologyBLASTP
36608173661521705N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
366178736634031617NaPi-cotransporter family proteinPhoU family proteinQuickGO ontologyBLASTP
3663709366410139330S ribosomal protein S9QuickGO ontologyBLASTP
3664127366456143550S ribosomal protein L13QuickGO ontologyBLASTP
36646853665425741tRNA pseudouridine synthase AQuickGO ontologyBLASTP
36654253666228804cobalt ABC transporter permeaseQuickGO ontologyBLASTP
36662253667091867cobalt transporter ATP-binding subunitQuickGO ontologyBLASTP
36670763667924849cobalt transporter ATP-binding subunitQuickGO ontologyBLASTP
3668015366835634250S ribosomal protein L17QuickGO ontologyBLASTP
36684003669347948DNA-directed RNA polymerase subunit alphaQuickGO ontologyBLASTP
3669415367003562130S ribosomal protein S4QuickGO ontologyBLASTP
3670070367046839930S ribosomal protein S11QuickGO ontologyBLASTP
3670486367085737230S ribosomal protein S13QuickGO ontologyBLASTP
3670970367108311450S ribosomal protein L36QuickGO ontologyBLASTP
36711003671318219translation initiation factor IF-1QuickGO ontologyBLASTP
36713263671607282hypothetical proteinBLASTP
36716223672371750methionine aminopeptidaseQuickGO ontologyBLASTP
36723713673021651adenylate kinaseQuickGO ontologyBLASTP
367304536743221278preprotein translocase subunit SecYQuickGO ontologyBLASTP
3674323367476344150S ribosomal protein L15QuickGO ontologyBLASTP
3674783367496218050S ribosomal protein L30QuickGO ontologyBLASTP
3674976367547349830S ribosomal protein S5QuickGO ontologyBLASTP
3675491367585036050S ribosomal protein L18QuickGO ontologyBLASTP
3675869367641154350S ribosomal protein L6QuickGO ontologyBLASTP
3676435367683339930S ribosomal protein S8QuickGO ontologyBLASTP
3676863367704818630S ribosomal protein S14QuickGO ontologyBLASTP
3677065367760754350S ribosomal protein L5QuickGO ontologyBLASTP
3677630367794731850S ribosomal protein L24QuickGO ontologyBLASTP
3677971367833936950S ribosomal protein L14QuickGO ontologyBLASTP
3678374367862825530S ribosomal protein S17QuickGO ontologyBLASTP
3678650367886221350S ribosomal protein L29QuickGO ontologyBLASTP
3678852367929544450S ribosomal protein L16QuickGO ontologyBLASTP
3679313367998467230S ribosomal protein S3QuickGO ontologyBLASTP
3680002368033733650S ribosomal protein L22QuickGO ontologyBLASTP
3680359368064328530S ribosomal protein S19QuickGO ontologyBLASTP
3680713368154683450S ribosomal protein L2QuickGO ontologyBLASTP
3681601368189429450S ribosomal protein L23QuickGO ontologyBLASTP
3681894368251462150S ribosomal protein L4QuickGO ontologyBLASTP
3682539368316863050S ribosomal protein L3QuickGO ontologyBLASTP
3683258368356630930S ribosomal protein S10QuickGO ontologyBLASTP
368396336851561194elongation factor TuQuickGO ontologyBLASTP
368519636872652070elongation factor GQuickGO ontologyBLASTP