Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:2731995 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2731995273238739330S ribosomal protein S9QuickGO ontologyBLASTP
2732414273284843550S ribosomal protein L13QuickGO ontologyBLASTP
27329952733729735tRNA pseudouridine synthase AQuickGO ontologyBLASTP
27338872734693807hypothetical proteinBLASTP
27347092735566858probable ABC transporterQuickGO ontologyBLASTP
27355512736396846probable ABC transporterQuickGO ontologyBLASTP
2736819273716034250S ribosomal protein L17QuickGO ontologyBLASTP
27371772738124948DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
2738209273882962130S ribosomal protein S4QuickGO ontologyBLASTP
2738853273963077830S ribosomal protein S11QuickGO ontologyBLASTP
2739265273963036630S ribosomal protein S13QuickGO ontologyBLASTP
2739867273998011450S ribosomal protein L36QuickGO ontologyBLASTP
27399932740211219translation initiation factor IF-1QuickGO ontologyBLASTP
27402192740527309hypothetical proteinBLASTP
27405862741335750methionyl aminopeptidaseQuickGO ontologyBLASTP
27413352741991657adenylate kinaseQuickGO ontologyBLASTP
274201227432891278preprotein translocase SecYQuickGO ontologyBLASTP
2743292274373244150S ribosomal protein L15QuickGO ontologyBLASTP
2743766274393917450S ribosomal protein L30QuickGO ontologyBLASTP
2743951274444849830S ribosomal protein S5QuickGO ontologyBLASTP
2744469274482836050S ribosomal protein L18QuickGO ontologyBLASTP
2744859274539854050S ribosomal protein L6QuickGO ontologyBLASTP
2745495274589339930S ribosomal protein S8QuickGO ontologyBLASTP
2745927274611218630S ribosomal protein S14QuickGO ontologyBLASTP
2746129274666854050S ribosomal protein L5QuickGO ontologyBLASTP
2746691274700531550S ribosomal protein L24QuickGO ontologyBLASTP
2747029274739736950S ribosomal protein L14QuickGO ontologyBLASTP
2747428274768225530S ribosomal protein S17QuickGO ontologyBLASTP
2747704274791321050S ribosomal protein L29QuickGO ontologyBLASTP
2747913274834743550S ribosomal protein L16QuickGO ontologyBLASTP
2748378274904666930S ribosomal protein S3QuickGO ontologyBLASTP
2749067274940233650S ribosomal protein L22QuickGO ontologyBLASTP
2749430274971128230S ribosomal protein S19QuickGO ontologyBLASTP
2749782275061583450S ribosomal protein L2QuickGO ontologyBLASTP
2750670275096329450S ribosomal protein L23QuickGO ontologyBLASTP
2751051275157852850S ribosomal protein L4QuickGO ontologyBLASTP
2751603275225365150S ribosomal protein L3QuickGO ontologyBLASTP
2752315275262330930S ribosomal protein S10QuickGO ontologyBLASTP
275331827545111194elongation factor TuQuickGO ontologyBLASTP
275458527566512067translation elongation factor EF-GQuickGO ontologyBLASTP
2756732275720247130S ribosomal protein S7QuickGO ontologyBLASTP
2757362275774238130S ribosomal protein S12QuickGO ontologyBLASTP
27578002758066267ribosomal protein L7AE familyQuickGO ontologyBLASTP
275815227616883537DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP