Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:3956500 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
39566053957345741tRNA pseudouridine synthase AQuickGO ontologyBLASTP
39573453958148804cobalt transport permease CbiQ familyQuickGO ontologyBLASTP
39581453959011867putative cobalt ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
39589963959844849putative cobalt ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
39599353960276342ribosomal protein L17QuickGO ontologyBLASTP
39603203961267948DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
39613353961955621ribosomal protein S4QuickGO ontologyBLASTP
39619903962388399ribosomal protein S11QuickGO ontologyBLASTP
39624063962777372ribosomal protein S13QuickGO ontologyBLASTP
39628903963003114ribosomal protein L36QuickGO ontologyBLASTP
39630203963238219translation initiation factor IF-1QuickGO ontologyBLASTP
39632463963527282hypothetical proteinBLASTP
39635423964291750methionine aminopeptidase type IQuickGO ontologyBLASTP
39642913964941651adenylate kinaseQuickGO ontologyBLASTP
396496539662421278preprotein translocase SecY subunitQuickGO ontologyBLASTP
39662433966683441ribosomal protein L15QuickGO ontologyBLASTP
39667033966882180ribosomal protein L30QuickGO ontologyBLASTP
39668963967393498ribosomal protein S5QuickGO ontologyBLASTP
39674113967770360ribosomal protein L18QuickGO ontologyBLASTP
39677893968331543ribosomal protein L6QuickGO ontologyBLASTP
39683553968753399ribosomal protein S8QuickGO ontologyBLASTP
39687833968968186ribosomal protein S14QuickGO ontologyBLASTP
39689853969527543ribosomal protein L5QuickGO ontologyBLASTP
39695503969867318ribosomal protein L24QuickGO ontologyBLASTP
39698913970259369ribosomal protein L14QuickGO ontologyBLASTP
39702943970548255ribosomal protein S17QuickGO ontologyBLASTP
39705703970782213ribosomal protein L29QuickGO ontologyBLASTP
39707723971215444ribosomal protein L16QuickGO ontologyBLASTP
39712333971904672ribosomal protein S3QuickGO ontologyBLASTP
39719223972257336ribosomal protein L22QuickGO ontologyBLASTP
39722793972563285ribosomal protein S19QuickGO ontologyBLASTP
39726333973466834ribosomal protein L2QuickGO ontologyBLASTP
39735213973814294ribosomal protein L23QuickGO ontologyBLASTP
39738143974434621ribosomal protein L4QuickGO ontologyBLASTP
39744593975088630ribosomal protein L3QuickGO ontologyBLASTP
39751783975486309ribosomal protein S10QuickGO ontologyBLASTP
397588339770761194translation elongation factor TuQuickGO ontologyBLASTP
397711639791852070translation elongation factor GQuickGO ontologyBLASTP
39792573979727471ribosomal protein S7QuickGO ontologyBLASTP
39798883980265378ribosomal protein S12QuickGO ontologyBLASTP
39803413980583243ribosomal protein L7Ae family proteinQuickGO ontologyBLASTP
398070539842413537DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
398426239879603699DNA-directed RNA polymerase beta subunitQuickGO ontologyBLASTP
39882353988606372ribosomal protein L7L12QuickGO ontologyBLASTP
39886543989154501ribosomal protein L10QuickGO ontologyBLASTP
39893563990045690ribosomal protein L1QuickGO ontologyBLASTP
39901023990527426ribosomal protein L11QuickGO ontologyBLASTP
39905983991122525transcription terminationantitermination factor NusGQuickGO ontologyBLASTP
39911693991396228preprotein translocase SecE subunitQuickGO ontologyBLASTP
39914463991595150ribosomal protein L33QuickGO ontologyBLASTP
399179739929901194translation elongation factor TuQuickGO ontologyBLASTP
3993073399314876tRNA-ThrQuickGO ontologyBLASTP
3993166399324277tRNA-GlyQuickGO ontology
39933063993947642RNA polymerase sigma-H factorQuickGO ontologyBLASTP
39940213994530510hypothetical proteinBLASTP
39945333995306774RNA methyltransferase TrmH family group 3QuickGO ontologyBLASTP
39953093996061753thymidylate synthase flavin-dependentQuickGO ontologyBLASTP
39960513996491441RNase3 domain proteinQuickGO ontologyBLASTP