Query: NC_002755:831397 Mycobacterium tuberculosis CDC1551, complete genome
Start: 831397, End: 850054, Length: 18658
Host Lineage: Mycobacterium tuberculosis; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria
General Information: This strain, also nicknamed "Oshkosh", is a recent clinical isolate from a clothing factory worker from the Kentucky/Tennessee, USA, region. It is highly contagious, infecting approximately 80% of the patient's social contacts. However, this strain has not caused epidemics in man and is sensitive to a wide range of drugs. It is also highly virulent in a mouse lung model, producing several orders of magnitude more bacteria than the H37Rv strain when inoculated. Causative agent of tuberculosis. Like other closely related Actinomycetales, such as Nocardia and Corynebacterium, mycobacteria have unusually high genomic DNA GC content and are capable of producing mycolic acids as major components of their cell wall. This bacterium is the causative agent of tuberculosis - a chronic infectious disease with a growing incidence worldwide. It infects 1.7 billion people a year (~33% of the entire world population) and causes over 3 million deaths/year. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. This bacterium does not form a polysaccharide capsule, and is an extremely slow growing obligate aerobe. The sluggish growth rate is a result of the tough cell wall that resists the passage of nutrients into the cell and inhibits waste products to be excreted out of the cell. The specialized cell envelope of this organism resembles a modified Gram positive cell wall. It also contains complex fatty acids, such as mycolic acids, that cause the waxy appearance and impermeability of the envelope. These acids are found bound to the cell envelope, but also form cord factors when linked with a carbohydrate component to form a cord-like structure. Primary infection occurs by inhalation of the organism in droplets that are aerosolized by an infected person. The organism initially replicates in cells of the terminal airways, after which it is taken up by, and replicates in, alveolar macrophages. Macrophages distribute the organism to other areas of the lungs and the regional lymph nodes. Once a cell-mediated hypersensitivity immune response develops, replication of the organism decreases and the bacteria become restricted to developing granulomas.
Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!
Subject Island | Start | End | Length | Subject Host Description | E-value | Bit score | Visual BLASTN | Visual BLASTP |
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NC_009565:833076 | 833076 | 851782 | 18707 | Mycobacterium tuberculosis F11, complete genome | 0 | 11900 | BLASTN svg | BLASTP svg |
NC_009525:830513 | 830513 | 849219 | 18707 | Mycobacterium tuberculosis H37Ra, complete genome | 0 | 11900 | BLASTN svg | BLASTP svg |
NC_002945:831029 | 831029 | 853656 | 22628 | Mycobacterium bovis AF2122/97, complete genome | 0 | 11880 | BLASTN svg | BLASTP svg |
NC_012207:831030 | 831030 | 853609 | 22580 | Mycobacterium bovis BCG str. Tokyo 172, complete genome | 0 | 11870 | BLASTN svg | BLASTP svg |
NC_008769:860670 | 860670 | 879696 | 19027 | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome | 0 | 11870 | BLASTN svg | BLASTP svg |
NC_008595:2546696 | 2546696 | 2584803 | 38108 | Mycobacterium avium 104, complete genome | 0 | 1281 | BLASTN svg | BLASTP svg |
NC_015848:3851230 | 3851230 | 3876717 | 25488 | Mycobacterium canettii CIPT 140010059, complete genome | 5e-66 | 260 | BLASTN svg | BLASTP svg |
NC_019950:3139865* | 3139865 | 3163501 | 23637 | Mycobacterium canettii CIPT 140060008 complete genome | 5e-32 | 147 | BLASTN svg | BLASTP svg |
NC_015848:3175692 | 3175692 | 3199118 | 23427 | Mycobacterium canettii CIPT 140010059, complete genome | 5e-32 | 147 | BLASTN svg | BLASTP svg |
NC_004463:2344128 | 2344128 | 2365099 | 20972 | Bradyrhizobium japonicum USDA 110, complete genome | 1e-23 | 119 | BLASTN svg | BLASTP svg |
NC_015556:819503* | 819503 | 842901 | 23399 | Pseudomonas fulva 12-X chromosome, complete genome | 2e-22 | 115 | BLASTN svg | BLASTP svg |
NC_005085:1498000 | 1498000 | 1521578 | 23579 | Chromobacterium violaceum ATCC 12472, complete genome | 2e-19 | 105 | BLASTN svg | BLASTP svg |
NC_020133:5020500 | 5020500 | 5042741 | 22242 | Mycobacterium liflandii 128FXT, complete genome | 2e-15 | 91.7 | BLASTN svg | BLASTP svg |
NC_021150:1322000 | 1322000 | 1357157 | 35158 | Azotobacter vinelandii CA6, complete genome | 1e-14 | 89.7 | BLASTN svg | BLASTP svg |
NC_012560:1322000 | 1322000 | 1357145 | 35146 | Azotobacter vinelandii DJ, complete genome | 1e-14 | 89.7 | BLASTN svg | BLASTP svg |
NC_011004:4183993* | 4183993 | 4226294 | 42302 | Rhodopseudomonas palustris TIE-1, complete genome | 1e-14 | 89.7 | BLASTN svg | BLASTP svg |
NC_010612:5403000 | 5403000 | 5421412 | 18413 | Mycobacterium marinum M, complete genome | 4e-14 | 87.7 | BLASTN svg | BLASTP svg |
NC_015677:285896* | 285896 | 309706 | 23811 | Ramlibacter tataouinensis TTB310 chromosome, complete genome | 2e-13 | 85.7 | BLASTN svg | BLASTP svg |
NC_012803:1552122* | 1552122 | 1579960 | 27839 | Micrococcus luteus NCTC 2665, complete genome | 2e-12 | 81.8 | BLASTN svg | BLASTP svg |
NC_012803:1094679* | 1094679 | 1115813 | 21135 | Micrococcus luteus NCTC 2665, complete genome | 2e-12 | 81.8 | BLASTN svg | BLASTP svg |
NC_013757:2858327 | 2858327 | 2877564 | 19238 | Geodermatophilus obscurus DSM 43160, complete genome | 9e-12 | 79.8 | BLASTN svg | BLASTP svg |
NC_010612:6113155 | 6113155 | 6132654 | 19500 | Mycobacterium marinum M, complete genome | 1e-10 | 75.8 | BLASTN svg | BLASTP svg |
NC_020133:5710661 | 5710661 | 5732244 | 21584 | Mycobacterium liflandii 128FXT, complete genome | 1e-10 | 75.8 | BLASTN svg | BLASTP svg |
NC_020133:1443934 | 1443934 | 1466099 | 22166 | Mycobacterium liflandii 128FXT, complete genome | 1e-10 | 75.8 | BLASTN svg | BLASTP svg |
NC_000962:3781501 | 3781501 | 3807573 | 26073 | Mycobacterium tuberculosis H37Rv, complete genome | 6e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_002755:3773734 | 3773734 | 3798448 | 24715 | Mycobacterium tuberculosis CDC1551, complete genome | 6e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_002945:3735141 | 3735141 | 3760774 | 25634 | Mycobacterium bovis AF2122/97, complete genome | 6e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_008769:3769065 | 3769065 | 3794701 | 25637 | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome | 6e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_009525:3794000 | 3794000 | 3816251 | 22252 | Mycobacterium tuberculosis H37Ra, complete genome | 6e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_009565:3793976 | 3793976 | 3818690 | 24715 | Mycobacterium tuberculosis F11, complete genome | 6e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_012207:3766978 | 3766978 | 3792614 | 25637 | Mycobacterium bovis BCG str. Tokyo 172, complete genome | 6e-10 | 73.8 | BLASTN svg | BLASTP svg |
NC_020133:2421965 | 2421965 | 2448099 | 26135 | Mycobacterium liflandii 128FXT, complete genome | 2e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_008027:713500 | 713500 | 734343 | 20844 | Pseudomonas entomophila L48, complete genome | 2e-09 | 71.9 | BLASTN svg | BLASTP svg |
NC_003143:2895617 | 2895617 | 2918099 | 22483 | Yersinia pestis CO92, complete genome | 9e-09 | 69.9 | BLASTN svg | BLASTP svg |
NC_004088:1291754 | 1291754 | 1314207 | 22454 | Yersinia pestis KIM, complete genome | 9e-09 | 69.9 | BLASTN svg | BLASTP svg |
NC_008149:1221637 | 1221637 | 1243315 | 21679 | Yersinia pestis Nepal516, complete genome | 9e-09 | 69.9 | BLASTN svg | BLASTP svg |
NC_011892:352652 | 352652 | 376099 | 23448 | Methylobacterium nodulans ORS 2060 plasmid pMNOD01, complete | 9e-09 | 69.9 | BLASTN svg | BLASTP svg |
NC_007963:2644930 | 2644930 | 2680189 | 35260 | Chromohalobacter salexigens DSM 3043, complete genome | 4e-08 | 67.9 | BLASTN svg | BLASTP svg |
NC_016002:2946702* | 2946702 | 2993761 | 47060 | Pseudogulbenkiania sp. NH8B, complete genome | 1e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_010002:4038500 | 4038500 | 4064763 | 26264 | Delftia acidovorans SPH-1, complete genome | 1e-07 | 65.9 | BLASTN svg | BLASTP svg |
NC_019974:3083899 | 3083899 | 3106188 | 22290 | Natronococcus occultus SP4, complete genome | 6e-07 | 63.9 | BLASTN svg | BLASTP svg |
NC_015711:1914162 | 1914162 | 1933958 | 19797 | Myxococcus fulvus HW-1 chromosome, complete genome | 2e-06 | 61.9 | BLASTN svg | BLASTP svg |
NC_015848:1647523 | 1647523 | 1670291 | 22769 | Mycobacterium canettii CIPT 140010059, complete genome | 9e-06 | 60 | BLASTN svg | BLASTP svg |
NC_009565:1629780 | 1629780 | 1656153 | 26374 | Mycobacterium tuberculosis F11, complete genome | 9e-06 | 60 | BLASTN svg | BLASTP svg |
NC_002945:1621765 | 1621765 | 1648262 | 26498 | Mycobacterium bovis AF2122/97, complete genome | 9e-06 | 60 | BLASTN svg | BLASTP svg |